Mitochondrial Biogenesis
(1) The Molecular Cardiology and Neuromuscular Institute, Highland Park, NJ, USA Abstract Mitochondria are not generated de novo but grow and divide adding newly synthesized constituents to preexisting mitochondrial…
Mechanisms of Bioenergy Production in Mitochondria
(1) The Molecular Cardiology and Neuromuscular Institute, Highland Park, NJ, USA Abstract The majority of the cellular energy is produced in the form of ATP by the oxidative phosphorylation…
Mitochondria Play an Essential Role in Heart Failure
(1) The Molecular Cardiology and Neuromuscular Institute, Highland Park, NJ, USA Abstract Both clinical studies and animal models have shown that mitochondria are at the center of the pathophysiology…
Heart Mitochondria: Receivers and Transmitters of Signals
(1) The Molecular Cardiology and Neuromuscular Institute, Highland Park, NJ, USA Abstract Besides their central bioenergetic role in supplying ATP, heart mitochondria play an essential role in the regulatory…
Mitochondria in Pediatric Cardiovascular Diseases
(1) The Molecular Cardiology and Neuromuscular Institute, Highland Park, NJ, USA Abstract Abnormalities in cardiac mitochondrial respiratory enzymes and mitochondrial DNA have been found in an increasing number of…
Mitochondrial Structure, Composition, and Dynamics
(1) The Molecular Cardiology and Neuromuscular Institute, Highland Park, NJ, USA Abstract Mitochondria are dynamic organelles displaying considerable structural complexity and diversity in terms of the folding of their…
Current Progress and Future Perspectives: Toward Mitochondrial Medicine
(1) The Molecular Cardiology and Neuromuscular Institute, Highland Park, NJ, USA Abstract Mitochondrial disorders encompass a highly heterogeneous group of diseases characterized by not only defects in the OXPHOS…
Cell-Death Pathways and Mitochondria
(1) The Molecular Cardiology and Neuromuscular Institute, Highland Park, NJ, USA Abstract All multicellular organisms develop during their evolution highly regulated and interconnected pathways of cell death. While cell…
Targeting the Mitochondria in Cardiovascular Diseases
(1) The Molecular Cardiology and Neuromuscular Institute, Highland Park, NJ, USA Abstract While progress achieved in mitochondrial research has been mainly used in the discovery of the pathogenesis of…
The Role of Mitochondria in the Metabolic Syndrome and Insulin Resistance
(1) The Molecular Cardiology and Neuromuscular Institute, Highland Park, NJ, USA Abstract Recent studies indicate that mitochondrial function is altered in the insulin-resistant myocardium, and this contributes to complex…
