Principles of Heart Failure
Fig. 1.1 Myocardial infarction culminating in heart failure; the direct consequences of myocardial infarction and the subsequent local and peripheral responses designed to protect the body from the effects of…
Ventricular Remodeling for Ischemic Cardiomyopathy and Ventricular Asynergy Post Myocardial Infarction
Indications •Anteroseptal myocardial infarction •Congestive heart failure •Depressed ejection fraction % •Large area of akinesis/dyskinesis –Asynergy of >30 % of LV surface •Enlarged ventricle –End-diastolic volume index >120 cc/m2 –End-systolic…
Algorithm for Treatment of Advanced Heart Failure
Fig. 2.1 Heart failure staging system (Adapted from Hunt SA, Abraham WT, Chin MH, Feldman AM, Francis GS, Ganiats TG, et al. ACC/AHA 2005 Guideline Update for the Diagnosis and…
Right Ventricular Dysfunction in Patients Undergoing Left Ventricular Assist Device Implantation: Predictors, Management, and Device Utilization
6. Frazier OH, Rose EA, Oz MC, Dembitsky W, McCarthy P, Radovancevic B, et al. Multicenter clinical evaluation of the HeartMate vented electric left ventricular assist system in patients awaiting…
Mitral Valve Repair for Ischemic Mitral Regurgitation with Advanced Cardiomyopathy
Baseline 1 year 1.5 years 2 years MR grade 2.54 ± 0.81 (N = 70) 0.52 ± 0.66* (N = 46) 0.35 ± 0.63* (N = 33) 0.48 ±…
Surgical Coronary Artery Revascularization in Patients with Advanced Ischemic Cardiomyopathy
3. Velazquez E, Lee K, Deja M, Jain A, Sopko G, Marchenko A, et al. Coronary-artery bypass surgery in patients with left ventricular dysfunction. N Engl J Med. 2011;364:1607–16.PubMedCrossRef 4….
Lung Vascular Regeneration and Repair
Fig. 15.1 Circulating and resident cells involved in neoangiogenesis. This figure depicts the rare circulating low proliferative potential (LPP) and high proliferative potential endothelial colony forming cells (HPP-ECFC) that may…
Role of Mechanical Stress in Lung Repair and Regeneration
Fig. 12.1 Growth and development of the lung are mechanically coupled to that of the thorax. Adapted from [5] Innate Potential for Compensatory Lung Growth Lower vertebrates such as newts…
Regenerating the Respiratory Tract
Fig. 17.1 The stages of tracheal and lung development in human and mouse. Genetic regulation of mouse tracheal specification from foregut endoderm (Bmp4) and patterning (Shh) is indicated in bottom…
Directed Differentiation of Human Pluripotent Stem Cells into Lung and Airway Epithelial Cells
Tracheoesophageal fistula/esophageal atresia Congenital acinar hypoplasia Congenital alveolar hypoplasia Surfactant deficiency Bronchopulmonary dysplasia Cystic fibrosis Neuroendocrine hyperplasia of infancy Chronic obstructive pulmonary disease Asthma Idiopathic pulmonary fibrosis Infectious disease Cystic…
