Sudden Cardiac Death and Arrhythmia in CKD
Fig. 3.1 Sudden cardiac death rate according to stage of chronic kidney disease. Rates shown as events per 1,000 patient-years and were as follows: eGFR ≥60 ml/min, 3.8 (95 %…
FGF23 and Phosphate: Two Cardiovascular Toxins with Distinct Toxicity Profiles?
Fig. 8.1 Estimated prevalence of elevated Pi, PTH and FGF23 across the strata of chronic kidney disease. FGF23 is an early biomarker of renal dysfunction, and its increase precedes the…
Renal Congestion in Heart Failure
Fig. 9.1 Mechanisms involved in renal congestion in heart failure How Does Renal Congestion Lead to Worsening of Renal Function? As suggested above venous congestion (including renal vein) is an…
Novel Combination Therapy to Target Heart and Kidney
Compounds Adverse clinical cardiorenal outcomes Cardiac effects Vascular effects Renal effects Indoxyl sulfate Progression of CKD [26, 27] Increased collagen synthesis in NCF [34] Defective endothelial proliferation and wound repair…
Pulmonary Hypertension in CKD: A New Problem Child
Fig. 14.1 Diagnostic algorithm of PH Classification of Pulmonary Hypertension The World Health Organization (WHO) has condensed all forms of PH into five main groups [8] (Table 14.1). Group I…
Is “Me, Me, Me” the New “We, We, We”?: Can We Afford (Not) to Take the Plunge into the Personalised, Stratified Medicine Era?
Cancer type Cellular target Targeted agent Class of agent Colorectal [16–18] KRAS Cetuximab Monoclonal antibody against EGFR Breast [19, 20] HER2 Trastuzumab Monoclonal antibody HER2/Neu (EGFR2) Chronic myeloid leukaemia [21,…
Renal Sympathetic Denervation in the Management of Treatment-Resistant Hypertension
4. DiBona GF, Kopp UC. Neural control of renal function. Physiol Rev. 1997;77:75–197.PubMed 5. DiBona GF. Sympathetic nervous system influences on the kidney: role in hypertension. Am J Hypertens. 1989;2:119S–24.PubMed…
How to Use Inhibitors of the Renin-Angiotensin-Aldosterone System in Patients with CKD and Heart Failure
© Springer International Publishing Switzerland 2015David Goldsmith, Adrian Covic and Jonas Spaak (eds.)Cardio-Renal Clinical Challenges10.1007/978-3-319-09162-4_15 15. How to Use Inhibitors of the Renin-Angiotensin-Aldosterone System in Patients with CKD and Heart Failure Dan Gaiţă1 , Svetlana Moşteoru1 and Liviu Segall2 (1)…
Small Vessel Disease in CKD, Diabetes, Obesity and Hypertension
© Springer International Publishing Switzerland 2015David Goldsmith, Adrian Covic and Jonas Spaak (eds.)Cardio-Renal Clinical Challenges10.1007/978-3-319-09162-4_2 2. Small Vessel Disease in CKD, Diabetes, Obesity and Hypertension Reza Aghamohammadzadeh1 , Emma C. Wylie2 and Anthony M. Heagerty1 (1) Institute of Cardiovascular Sciences, The University…
Uric Acid, Allopurinol: The Cardio-Renal Silver Bullet?
28. Pereira MA, Fulgoni III VL. Consumption of 100% fruit juice and risk of obesity and metabolic syndrome: findings from the national health and nutrition examination survey 1999–2004. J Am…
