(1) The Molecular Cardiology and Neuromuscular Institute, Highland Park, NJ, USA Abstract Mitochondrial disorders encompass a highly heterogeneous group of diseases characterized by not only defects in the OXPHOS…
(1) The Molecular Cardiology and Neuromuscular Institute, Highland Park, NJ, USA Abstract All multicellular organisms develop during their evolution highly regulated and interconnected pathways of cell death. While cell…
(1) The Molecular Cardiology and Neuromuscular Institute, Highland Park, NJ, USA Abstract While progress achieved in mitochondrial research has been mainly used in the discovery of the pathogenesis of…
(1) The Molecular Cardiology and Neuromuscular Institute, Highland Park, NJ, USA Abstract Recent studies indicate that mitochondrial function is altered in the insulin-resistant myocardium, and this contributes to complex…
(1) The Molecular Cardiology and Neuromuscular Institute, Highland Park, NJ, USA Abstract Cardiac mitochondria are complex highly organized cellular organelles, which play central roles not only in energy homeostasis…
(1) The Molecular Cardiology and Neuromuscular Institute, Highland Park, NJ, USA Abstract The ability of thyroid hormone to regulate energy utilization was first recognized more than 100 years ago…
(1) The Molecular Cardiology and Neuromuscular Institute, Highland Park, NJ, USA Abstract Heart failure is common in patients with diabetes, even in the absence of coronary artery disease or…
(1) The Molecular Cardiology and Neuromuscular Institute, Highland Park, NJ, USA Abstract Under pathophysiological conditions, reactive oxygen species (ROS) levels may increase and cause cell damage and dysfunction targeting…
(1) The Molecular Cardiology and Neuromuscular Institute, Highland Park, NJ, USA Abstract Ischemia and postischemic reperfusion cause a wide array of functional and structural alterations of mitochondria. Although mitochondrial…
(1) The Molecular Cardiology and Neuromuscular Institute, Highland Park, NJ, USA Abstract The two opposing highly regulated processes, division (fission) and fusion, determine cell-type-specific mitochondrial morphology, intracellular distribution, and…
