Adhesion molecule Alternative designation Localisation Ligand Function Basal expression Selectin family P-selectin CD62P Endothelial cell L-selectin Rolling Yes PADGEM Platelet PSGL-1 GMP-140 120 kD PSL E-selectin CD62E Endothelial cell L-selectin…
Fig. 25.1 Familial Cardiomyopathies and genetic substrate (Image modified from original image courtesy of EKKAN) Fig. 25.2 Cardiomyopathies and overlapping in genetic substrates (Image reproduced courtesy of EKKAN) 25.1.1 Incomplete…
Fig. 17.1 Electron micrograph of an isolated adult cardiocyte A second thesis was supported since a long time by the group of Piero Anversa [12] (Fig. 17.2). According to Anversa…
Fig. 10.1 Excitation-contraction coupling in cardiac muscle. The initial event in the cardiac muscle contraction is membrane depolarization, which occurs with ion entry through connexon channels from a neighboring cardiomyocyte,…
Fig. 16.1 The inflammatory phase of cardiac repair. Release of damage-associated molecular patterns (DAMPs) by dying cardiomyocytes and matrix fragments activates innate immune pathways leading to recruitment of leukocytes in…
Fig. 13.1 The activation of innate and adaptive immune response in atherosclerosis. (a) The innate immune response. Modified LDL particles taken-up by scavenger receptors may activate the inflammasome, leading to…
Fig. 26.1 With blue color all reports, with red color reports using animal models 26.2 What Has Been Done The most frequently used animal models for studying cardiorenal syndrome are…
Fig. 20.1 Representation of several components of a single skinned cardiomyocyte setup (a) where a permeabilized (skinned) cardiomyocyte (b) is glued between a force transducer (FT) and a servomotor (SM)…
Fig. 30.1 The pathway to clinical translation. Vital steps along the path involve small-animal studies (proof-of-concept studies and studies to investigate the mechanism of action) and large-animal studies (to optimize…
Pathophysiology and epidemiology 1. Poor understanding of the pathophysiology in AHFS 2. Heterogeneous patient population in terms of pathophysiology, etiology, and clinical presentation 3. Uncertain relationship between hemodynamics and neurohormonal…
