Regenerating the Respiratory Tract
Fig. 17.1 The stages of tracheal and lung development in human and mouse. Genetic regulation of mouse tracheal specification from foregut endoderm (Bmp4) and patterning (Shh) is indicated in bottom…
Directed Differentiation of Human Pluripotent Stem Cells into Lung and Airway Epithelial Cells
Tracheoesophageal fistula/esophageal atresia Congenital acinar hypoplasia Congenital alveolar hypoplasia Surfactant deficiency Bronchopulmonary dysplasia Cystic fibrosis Neuroendocrine hyperplasia of infancy Chronic obstructive pulmonary disease Asthma Idiopathic pulmonary fibrosis Infectious disease Cystic…
Extracellular Matrix Specification of Regenerative Cells in the Adult Lung
Fig. 11.1 Second Harmonic Generation images of airway and parenchymal tissues from non-diseased and diseased lungs. Second Harmonic Generation signals from fibrillar collagen I propagated in the forward (Cyan) (representing…
Neural Regulation of Lung Development
Fig. 4.1 Development of the lung buds in the early chick embryo. At HH stage 17 (day 2.5) the laryngotracheal groove forms in the ventral foregut (F) and deepens over…
The Regulation of Branching Morphogenesis in the Developing Lung
Fig. 1.1 A complete developmental history of SOX9 lung epithelial progenitors. Optical projection tomography (OPT, top row, scale: 250 um) and confocal images (bottom row, scale: 20 um) of immunostained…
Acellular Lung Scaffolds in Lung Bioengineering
Fig. 18.1 Schematic of ex vivo organ engineering. Autologous cells are obtained by a biopsy from the eventual transplant recipient and expanded in ex vivo culture. A scaffold, either synthetic…
Fetal and Neonatal Origins of Lung Disease
Fig. 5.1 Histological representation of the alveolar region of a lung from (a; ×25 magnification) a term infant, and (b; ×50 magnification) a surfactant -treated preterm infant with BPD. Photomicrographs…
Mesenchymal Stromal Cell-Based Therapies for Lung Disease
Fig. 14.1 Turning the translational ‘leap’ into a step. The decision to move to a first-in-human study is difficult, but can be considered within the framework outlined in the figure….
Cellular Origins of Fibrotic Lung Diseases
© Springer International Publishing Switzerland 2015Ivan Bertoncello (ed.)Stem Cells in the LungStem Cell Biology and Regenerative Medicine10.1007/978-3-319-21082-7_13 13. Cellular Origins of Fibrotic Lung Diseases Vibha N. Lama1 (1) Division of Pulmonary and Critical Care Medicine, Department…
Immunomodulatory Regulation of Lung Regeneration and Repair
© Springer International Publishing Switzerland 2015Ivan Bertoncello (ed.)Stem Cells in the LungStem Cell Biology and Regenerative Medicine10.1007/978-3-319-21082-7_10 10. Immunomodulatory Regulation of Lung Regeneration and Repair Jonathan L. McQualter1 , Desiree Anthony2, Ross Vlahos1 and Steven Bozinovski1 (1) School of Health…
