Fig. 1.1 A complete developmental history of SOX9 lung epithelial progenitors. Optical projection tomography (OPT, top row, scale: 250 um) and confocal images (bottom row, scale: 20 um) of immunostained…
Fig. 18.1 Schematic of ex vivo organ engineering. Autologous cells are obtained by a biopsy from the eventual transplant recipient and expanded in ex vivo culture. A scaffold, either synthetic…
Fig. 5.1 Histological representation of the alveolar region of a lung from (a; ×25 magnification) a term infant, and (b; ×50 magnification) a surfactant -treated preterm infant with BPD. Photomicrographs…
Fig. 14.1 Turning the translational ‘leap’ into a step. The decision to move to a first-in-human study is difficult, but can be considered within the framework outlined in the figure….
© Springer International Publishing Switzerland 2015Ivan Bertoncello (ed.)Stem Cells in the LungStem Cell Biology and Regenerative Medicine10.1007/978-3-319-21082-7_13 13. Cellular Origins of Fibrotic Lung Diseases Vibha N. Lama1 (1) Division of Pulmonary and Critical Care Medicine, Department…
© Springer International Publishing Switzerland 2015Ivan Bertoncello (ed.)Stem Cells in the LungStem Cell Biology and Regenerative Medicine10.1007/978-3-319-21082-7_10 10. Immunomodulatory Regulation of Lung Regeneration and Repair Jonathan L. McQualter1 , Desiree Anthony2, Ross Vlahos1 and Steven Bozinovski1 (1) School of Health…
Fig. 9.1 Mesenchymal progenitors support epithelial regeneration via the release of growth factors like FGF-10 which promote the proliferation of epithelial stem/progenitor cells . The differentiation of mesenchymal progenitors cells…
Fig. 7.1 Stem cells of the distal bronchiolar airways. (a) Murine distal airways are primarily composed of ciliated, secretory (Club), and neuroendocrine cells. Lineage tracing studies using genetically modified mouse…
104. Chamoto K et al (2013) Migration of CD11b+ accessory cells during murine lung regeneration. Stem Cell Res 10(3):267–277PubMedCentralPubMed 105. Sun Z et al (2014) Inhibition of Wnt/beta-catenin signaling promotes…
Fig. 2.1 Epithelial-mesenchymal-endothelial-nerve-matrix crosstalk in early mouse lung . This concept figure diagrams many of the known interactions between these compartments in lung morphogenesis. In the proximal lung, Sox9-positive mesenchymal…
