Interstitial Lung Disease in Systemic Sclerosis
Fig. 25.1 Cellular NSIP. The lung shows diffuse involvement of the alveolar interstitium by a mild chronic inflammatory infiltrate Fig. 25.2 Fibrotic NSIP. The lung shows diffuse involvement of the…
Pulmonary Manifestations of Hematological Malignancies: Focus on Pulmonary Chronic Graft-Versus Host Disease
Antibiotic chemotherapeutic agents Bleomycin, Mitomycin C Alkylating agents Busulfan, Cyclophosphamide, Chlorambucil, Melphalan, Ifosfamide, Procarbazine Antimetabolites Methotrexate, 6-mercaptopurine, Cytosine arabinoside, Fludarabine Nitrosamines Bischloroethyl nitrosourea (BCNU), Chloroethyl cyclohexyl nitrosourea (CCNU), Methyl-CCNU Tubulin-acting…
Pulmonary Hypertension in Orphan Lung Diseases
1. Pulmonary arterial hypertension 1.1 Idiopathic PAH 1.2 Heritable 1.2.1. BMPR2 1.2.2. ALK1, endoglin, SMAD9, CAV1, KCNK3 1.2.3 Unknown 1.3 Drug- and toxin-induced 1.4 Associated with 1.4.1. Connective tissue diseases…
Hepatopulmonary Syndrome
1. Presence of liver disease (a) Cirrhotic or non-cirrhotic portal hypertension 2. Intrapulmonary vascular dilatations (a) Positive transthoracic contrast/bubble echocardiogram (b) 99mTechnetium lung/brain perfusion scan 3. Hypoxemia (a) Seated room…
Pulmonary Involvement in Takayasu Arteritis and Behçet Disease
1. Age at disease onset <40 years Development of symptoms or findings related to Takayasu arteritis at age <40 years 2. Claudication of extremities Development and worsening of fatigue and…
Amyloidosis and the Respiratory Tract
Type Fibril protein precursor Clinical syndrome AA Serum amyloid A protein Reactive systemic amyloidosis associated with chronic inflammatory diseases AL Monoclonal immunoglobulin light chains Systemic amyloidosis associated with monoclonal plasma…
Pulmonary Vascular Manifestations of Hereditary Hemorrhagic Telangiectasia
Fig. 12.1 (a) Case 1: Chest x-ray shows that the left diaphragm is obscured by a pleural effusion. The abdomen is protected by a lead shield. (b–d) Case 1: CT…
The Challenges of Clinical Research in Orphan Diseases
Increasing awareness of rare diseases throughout society Defining disease mechanisms and targets – encourage basic research Improving case definition Improving methods of diagnosis and screening Standardizing methods for sample manipulation…
Systems Biology Approaches to Understanding and Predicting Fungal Virulence
Fig. 3.1. The “bench–desk–bench” loop of SysBio. A typical SysBio workflow. Based on an observation, such as a difference in yeast colony size and phenotype under two different conditions, a…
Diagnostics of Fungal Infections
Fig. 13.1. Angioinvasive aspergillosis in a 35-year-old man with acute lymphatic leukemia. CT scan shows bilateral peribronchovascular nodular lung lesions with surrounding halo of ground-glass attenuation representing adjacent hemorrhage Fig….
