Pulmonary Vascular Development
Figure 3-1. Casts of the airway (yellow/white), arterial (red) and venous (blue) systems in the human lung. Courtesy of Prof. Ewald Weibel, Institute of Anatomy, University of Berne. The vessels…
Transcriptional Mechanisms Regulating Pulmonary Epithelial Maturation:
Figure 4-1. Systems biology to integrate complex data. Lung Ventilation at Birth Is Dependent on Its Structure How do the alveoli form? What are the cellular and molecular processes mediating…
The Genetic Programs Regulating Embryonic Lung Development and Induced Pluripotent Stem Cell Differentiation
Figure 1-1. Overview of lung development. (A) A time line showing the major steps of lung development in the mouse and (B) a diagram showing the ontology of cell lineages…
Early Development of the Mammalian Lung-Branching Morphogenesis
Figure 2-1. Reciprocal interactions between the developing lung endoderm and mesenchyme promote growth and branching of the airways. The developing lung airways are patterned in a proximal–distal manner with mesenchymal…
Physiologic Assessment of Lung Growth and Development Throughout Infancy and Childhood
Figure 14-1. Photo of a child having infant lung function testing. The child has been sedated with chloral hydrate and has had a mask with pneumotachograph attached to their face…
Apnea and Control of Breathing
Figure 12-1. Simplified schematic view of the ventral mammalian brain stem. Rhythm generation resides mainly in the pre-Bötzinger (pre-BötC) complex, while pattern formation resides more caudally in the ventral respiratory…
Initiation of Breathing at Birth
Figure 9-1. (A) Changes in FRC of rabbit pups (30 days) treated with either an epithelial sodium channel blocker (amiloride; filled circles) or saline (open circles) and mechanically ventilated from…
Congenital Malformations of the Lung
Figure 6-1. Tracheal agenesis with bronchoesophageal fistula. An infant boy was born at 36 weeks gestation after a pregnancy complicated by idiopathic polyhydramnios, a prenatal evaluation showing normal chromosome karyotype,…
The Lung Structure Maintenance Program: Sustaining Lung Structure during Adulthood and Implications for COPD Risk
Figure 17-1. An illustration of the concept of the lung structure maintenance program. There are several homeostatic balances that contribute to lung cell growth and repair in response to environmental…
Lung Structure at Preterm and Term Birth
Figure 7-1. Airway branching with gestational age. The stages of lung development and the development of the bronchial tree. On average an airway of a human lung ends after approximately…
