Mesenchymal Stromal Cell-Based Therapies for Lung Disease
Fig. 14.1 Turning the translational ‘leap’ into a step. The decision to move to a first-in-human study is difficult, but can be considered within the framework outlined in the figure….
Cellular Origins of Fibrotic Lung Diseases
© Springer International Publishing Switzerland 2015Ivan Bertoncello (ed.)Stem Cells in the LungStem Cell Biology and Regenerative Medicine10.1007/978-3-319-21082-7_13 13. Cellular Origins of Fibrotic Lung Diseases Vibha N. Lama1 (1) Division of Pulmonary and Critical Care Medicine, Department…
Immunomodulatory Regulation of Lung Regeneration and Repair
© Springer International Publishing Switzerland 2015Ivan Bertoncello (ed.)Stem Cells in the LungStem Cell Biology and Regenerative Medicine10.1007/978-3-319-21082-7_10 10. Immunomodulatory Regulation of Lung Regeneration and Repair Jonathan L. McQualter1 , Desiree Anthony2, Ross Vlahos1 and Steven Bozinovski1 (1) School of Health…
Stem Cells of the Distal Bronchiolar Airways
Fig. 7.1 Stem cells of the distal bronchiolar airways. (a) Murine distal airways are primarily composed of ciliated, secretory (Club), and neuroendocrine cells. Lineage tracing studies using genetically modified mouse…
Stromal Regulation of Lung Regeneration and Repair
Fig. 9.1 Mesenchymal progenitors support epithelial regeneration via the release of growth factors like FGF-10 which promote the proliferation of epithelial stem/progenitor cells . The differentiation of mesenchymal progenitors cells…
Regenerative Cells in the Ageing Lung
104. Chamoto K et al (2013) Migration of CD11b+ accessory cells during murine lung regeneration. Stem Cell Res 10(3):267–277PubMedCentralPubMed 105. Sun Z et al (2014) Inhibition of Wnt/beta-catenin signaling promotes…
Epithelial–Mesenchymal Crosstalk in Lung Development
Fig. 2.1 Epithelial-mesenchymal-endothelial-nerve-matrix crosstalk in early mouse lung . This concept figure diagrams many of the known interactions between these compartments in lung morphogenesis. In the proximal lung, Sox9-positive mesenchymal…
Lung Vasculogenesis and Angiogenesis
© Springer International Publishing Switzerland 2015Ivan Bertoncello (ed.)Stem Cells in the LungStem Cell Biology and Regenerative Medicine10.1007/978-3-319-21082-7_3 3. Lung Vasculogenesis and Angiogenesis Bernard Thébaud1 and Mervin C. Yoder2 (1) Division of Neonatology, Department of Pediatrics, Sinclair Centre…
Stem and Progenitor Cells of the Trachea and Proximal Airways
Fig. 6.1 Schematic representation of our current understanding of stem and progenitor cells responsible for maintenance and repair of the proximal airway surface epithelium and submucosal glands. LRC label retaining…
