© Springer Science+Business Media New York 2015James R. Klinger and Robert P. Frantz (eds.)Diagnosis and Management of Pulmonary HypertensionRespiratory Medicine1210.1007/978-1-4939-2636-7_17 17. Investigative Therapies in Pulmonary Arterial Hypertension Karen A. Fagan1 (1) Pulmonary Diseases and Critical Care Medicine,…
Abnormalities Subjects Reference Platelet aggregation related Increased urinary thromboxane metabolite (11 dehydroxy TxB2) IPAH [41] Decreased urinary PGI2 metabolite (PGI-M) IPAH [41] Decreased nitric oxide (exhaled or urinary excretion) IPAH,…
Definition Hemodynamic characteristics Pulmonary hypertension mPAP ≥ 25 mmHg Pre-capillary PH mPAP ≥ 25 mmHg PAOP ≤ 15 mmHg CO normal or reduced Post-capillary PH mPAP ≥ 25 mmHg PAOP > 15 mmHg Combined post-capillary and pre-capillary PH mPAP ≥ 25 mmHg…
Fig. 3.1 Signaling pathways downstream of BMPR2 Interestingly, it is clear that not all persons with BMPR2 mutation develop PAH and within the same family there is variation in age…
Fig. 13.1 Current driver for CardioWest TAH-t on left shown with new drivers drawn to scale: Companion Driver attached to patient weighs 18 kg, the much smaller Freedom Driver, further…
Fig. 10.1 HeartMate I XVE (courtesy of Thoratec Corp., used with permission) The device employs pusher plate technology to produce pulsatile flow with a stroke volume of 83 cm3 and…
Fig. 5.1 (a) Parasternal long-axis view with color flow imaging by transthoracic echocardiography shows severe aortic insufficiency. (b) Parasternal long-axis view shows severe annuloaortic ectasia causing poor coaptation of the…
Fig. 9.1 After opening of the pericardium, the aorta and pulmonary artery are isolated and dissected in preparation for division Figure 9.2 shows the lines of transaction for the SVC,…
Fig. 8.1 An algorithm depicting the potential courses of care for patients with severe cardiogenic shock The etiology of heart failure plays a major role in determining the ultimate course…
Fig. 12.1 The paracorporeal pulsatile left ventricular assist device used by Dr. Michael E. DeBakey in the 1960s (image property of Texas Heart Institute) Throughout the 1960s and 1970s, several…
