Reversible and Irreversible Damage of the Myocardium: Ischemia/Reperfusion Injury and Cardioprotection

Jul 10, 2016 by in CARDIAC SURGERY Comments Off on Reversible and Irreversible Damage of the Myocardium: Ischemia/Reperfusion Injury and Cardioprotection

Secondary determinants influencing MVO2 include (1) the relative heart rate, (2) myocardial stroke work, (3) imposed afterloads, and/or (4) the inotropic state of the myocardium. Importantly, associated with cardiac surgery,…

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Cardiac and Vascular Receptors and Signal Transduction

Jul 10, 2016 by in CARDIAC SURGERY Comments Off on Cardiac and Vascular Receptors and Signal Transduction

By location By receptor types Cardiac receptors • Myocardial • Conduction system • Others G protein-coupled receptors Tyrosine kinase-linked receptors Guanylyl cyclase-linked receptors Vascular receptors • Endothelial • Vascular smooth muscle • Others Other receptors (low-sensitivity…

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Current Status of Development and Regulatory Approval of Cardiac Devices

Jul 10, 2016 by in CARDIAC SURGERY Comments Off on Current Status of Development and Regulatory Approval of Cardiac Devices

•Adverse local tissue interactions:   – Inflammation   – Toxicity   – Carcinogenic response   – Calcification   – Embolization or lymphatic spread of material fragments •Induced device migrations: encapsulation or foreign body response •Inappropriate…

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Congenital Cardiac Anatomy and Operative Correction

Jul 10, 2016 by in CARDIAC SURGERY Comments Off on Congenital Cardiac Anatomy and Operative Correction

Acyanotic  • Left-to-right shunts Atrial septal defects Ventricular septal defects Atrioventricular septal defects Aortopulmonary window  • Left-sided obstructive lesions Aortic coarctation Congenital aortic stenosis Interrupted aortic arch  Cyanotic  • Right-to-left…

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The Effects of Anesthetic Agents on Cardiac Function

Jul 10, 2016 by in CARDIAC SURGERY Comments Off on The Effects of Anesthetic Agents on Cardiac Function

  Minimal sedation (anxiolysis) Moderate sedation/analgesia (“conscious sedation”) Deep sedation/analgesia General anesthesia Responsiveness Normal response to verbal stimulation Purposeful response to verbal or tactile stimulation Purposeful response following repeated or…

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Pharmacotherapy for Cardiac Diseases

Jul 10, 2016 by in CARDIAC SURGERY Comments Off on Pharmacotherapy for Cardiac Diseases

• Tobacco use • Dyslipidemia • Overweight (body mass index > 25 kg/m2) • Diabetes mellitus • Age (>45 years for men; >55 years for women) • Physical inactivity • Family history…

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