Response to comment on: Yoga vs regular exercise for atrial fibrillation – design considerations for the yoga-AF randomized trial

Jun 27, 2026 by in CARDIOLOGY Comments Off on Response to comment on: Yoga vs regular exercise for atrial fibrillation – design considerations for the yoga-AF randomized trial
We thank Dr Shridevi and colleagues for their feedback on the yoga AF trial and seek to address the important points raised. Untangling the impact of yoga from the benefits…
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A multicenter trial to test pitavastatin calcium in youth with combined dyslipidemia of obesity: Design, implementation, challenges, and responses

Jun 27, 2026 by in CARDIOLOGY Comments Off on A multicenter trial to test pitavastatin calcium in youth with combined dyslipidemia of obesity: Design, implementation, challenges, and responses
Highlights • DO IT! is the first trial designed to test statins in childhood combined dyslipidemia of obesity. • Rigorous double-blind randomized trial included vascular, lipid and safety outcomes. •…
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Design and rationale of CATO, a Phase IIA, randomized, double-blind, placebo-controlled study of single or repeated intravenous administration of umbilical cord-derived mesenchymal stromal cells in ischemic cardiomyopathy

Jun 27, 2026 by in CARDIOLOGY Comments Off on Design and rationale of CATO, a Phase IIA, randomized, double-blind, placebo-controlled study of single or repeated intravenous administration of umbilical cord-derived mesenchymal stromal cells in ischemic cardiomyopathy
Highlights • CATO tests 2 new strategies in HF (intravenous cell therapy and multiple cell doses). • It is a Phase IIA randomized, double-blind, placebo-controlled, multicenter study. • Patients with…
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Large-bore mechanical thrombectomy vs standard of care for acute high-risk pulmonary embolism: Rationale and design of the PERSEVERE randomized controlled trial

Jun 27, 2026 by in CARDIOLOGY Comments Off on Large-bore mechanical thrombectomy vs standard of care for acute high-risk pulmonary embolism: Rationale and design of the PERSEVERE randomized controlled trial
Abstract Background Catheter-directed therapies are increasingly used to treat acute pulmonary embolism (PE). However, randomized data on reperfusion treatments, including large-bore mechanical thrombectomy (LBMT), for patients with High-Risk PE are…
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Design and rationale of the HD PCI trial: A cluster randomized crossover trial of higher vs. lower dose heparin for elective percutaneous coronary intervention

Jun 27, 2026 by in CARDIOLOGY Comments Off on Design and rationale of the HD PCI trial: A cluster randomized crossover trial of higher vs. lower dose heparin for elective percutaneous coronary intervention
ABSTRACT Background Balancing ischemic versus bleeding complications following percutaneous coronary intervention (PCI) remains challenging. However, the optimal dose of unfractionated heparin (UFH) for elective PCI is currently unclear. Methods A…
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Caribbean and South American team-based strategy to control hypertension (CATCH): Rationale and study design of a cluster randomized trial

Jun 27, 2026 by in CARDIOLOGY Comments Off on Caribbean and South American team-based strategy to control hypertension (CATCH): Rationale and study design of a cluster randomized trial
ABSTRACT Rationale Hypertension disproportionately affects populations in low- and middle-income countries (LMICs), especially in Latin America and the Caribbean, due to its high prevalence and low control rate. Primary Hypothesis…
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Coronary computed tomography angiography versus invasive coronary angiography for interventional triage in acute coronary syndrome: Design of the randomized TRACTION trial

Jun 27, 2026 by in CARDIOLOGY Comments Off on Coronary computed tomography angiography versus invasive coronary angiography for interventional triage in acute coronary syndrome: Design of the randomized TRACTION trial
ABSTRACT Purpose In patients admitted with acute coronary syndrome, invasive coronary angiography (ICA) is performed to determine which patients need revascularization. Coronary computed tomography angiography (CCTA) offers a widely available,…
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