Efficacy, Safety, Tolerability, and Pharmacokinetic Profile of Evacetrapib Administered as Monotherapy or in Combination With Atorvastatin in Japanese Patients With Dyslipidemia

Dec 1, 2016 by in CARDIOLOGY Comments Off on Efficacy, Safety, Tolerability, and Pharmacokinetic Profile of Evacetrapib Administered as Monotherapy or in Combination With Atorvastatin in Japanese Patients With Dyslipidemia

The cholesteryl ester transfer protein (CETP) inhibitor evacetrapib has been previously shown to increase high-density lipoprotein cholesterol (HDL-C) and decrease low-density lipoprotein cholesterol (LDL-C) levels, as monotherapy or in combination…

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Long-Term Outcomes of Percutaneous Coronary Interventions or Coronary Artery Bypass Grafting for Left Main Coronary Artery Disease in Octogenarians (from a Drug-Eluting stent for LefT main Artery Registry Substudy)

Dec 1, 2016 by in CARDIOLOGY Comments Off on Long-Term Outcomes of Percutaneous Coronary Interventions or Coronary Artery Bypass Grafting for Left Main Coronary Artery Disease in Octogenarians (from a Drug-Eluting stent for LefT main Artery Registry Substudy)

Percutaneous coronary intervention (PCI) with drug-eluting stents is an accepted alternative to surgery for the treatment of unprotected left main coronary artery (ULMCA) disease, but the long-term outcome in elderly…

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Impact of Female Gender on Bleeding Complications After Transradial Coronary Intervention (from the Korean Transradial Coronary Intervention Registry)

Dec 1, 2016 by in CARDIOLOGY Comments Off on Impact of Female Gender on Bleeding Complications After Transradial Coronary Intervention (from the Korean Transradial Coronary Intervention Registry)

Besides poor clinical outcomes, female gender has been known as a high-risk factor for bleeding complications. This study aimed to investigate the impact of gender on clinical outcomes and bleeding…

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Performance of Bleeding Risk-Prediction Scores in Patients With Atrial Fibrillation Undergoing Percutaneous Coronary Intervention

Dec 1, 2016 by in CARDIOLOGY Comments Off on Performance of Bleeding Risk-Prediction Scores in Patients With Atrial Fibrillation Undergoing Percutaneous Coronary Intervention

The hypertension, abnormal renal/liver function, stroke, bleeding history or predisposition, labile international normalized ratio, elderly, and drugs/alcohol (HAS-BLED); anticoagulation and risk factors in atrial fibrillation (ATRIA); modified Outpatient Bleeding Risk…

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Application of the “Hybrid Approach” to Chronic Total Occlusions in Patients With Previous Coronary Artery Bypass Graft Surgery (from a Contemporary Multicenter US Registry)

Dec 1, 2016 by in CARDIOLOGY Comments Off on Application of the “Hybrid Approach” to Chronic Total Occlusions in Patients With Previous Coronary Artery Bypass Graft Surgery (from a Contemporary Multicenter US Registry)

Percutaneous coronary intervention (PCI) for chronic total occlusions (CTOs) has been traditionally associated with lower success rates in patients with previous coronary artery bypass graft surgery (CABG). We sought to…

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Impact of Cardiac Rehabilitation on Angiographic Outcomes After Drug-Eluting Stents in Patients With De Novo Long Coronary Artery Lesions

Dec 1, 2016 by in CARDIOLOGY Comments Off on Impact of Cardiac Rehabilitation on Angiographic Outcomes After Drug-Eluting Stents in Patients With De Novo Long Coronary Artery Lesions

Cardiac rehabilitation (CR) can reduce cardiovascular mortality and morbidity in coronary artery disease. Long coronary artery lesions may be associated with adverse outcomes after drug-eluting stent (DES) implantation. The purpose…

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Comparison of Frequency of Radial Artery Occlusion After 4Fr Versus 6Fr Transradial Coronary Intervention (from the Novel Angioplasty USIng Coronary Accessor Trial)

Dec 1, 2016 by in CARDIOLOGY Comments Off on Comparison of Frequency of Radial Artery Occlusion After 4Fr Versus 6Fr Transradial Coronary Intervention (from the Novel Angioplasty USIng Coronary Accessor Trial)

The frequency of radial artery occlusion was compared between patients receiving 4Fr versus 6Fr transradial coronary interventions (TRIs) in an open-label randomized trial ( ClinicalTrials.gov identifier: NCT00815997 ). The primary…

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Impact of Early Versus Late Clopidogrel Discontinuation on Stent Thrombosis Following Percutaneous Coronary Intervention With First- and Second-Generation Drug-Eluting Stents

Dec 1, 2016 by in CARDIOLOGY Comments Off on Impact of Early Versus Late Clopidogrel Discontinuation on Stent Thrombosis Following Percutaneous Coronary Intervention With First- and Second-Generation Drug-Eluting Stents

Premature antiplatelet therapy discontinuation (ATD) after drug-eluting stent (DES) implantation is known to predict stent thrombosis (ST). However, recent data suggest that a shorter antiplatelet therapy duration is safe with…

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Comparison of Left Ventricular Function Following First ST-Segment Elevation Myocardial Infarction Treated With Primary Percutaneous Coronary Intervention in Men Versus Women

Dec 1, 2016 by in CARDIOLOGY Comments Off on Comparison of Left Ventricular Function Following First ST-Segment Elevation Myocardial Infarction Treated With Primary Percutaneous Coronary Intervention in Men Versus Women

Previous data reported worse outcomes in female patients after acute ST elevation myocardial infarction (STEMI), related at least in part to less aggressive and nonparallel treatment. We investigated the presence…

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Analysis of the Invasive Strategy Decision in Patients With Acute Coronary Syndrome Without ST-Segment Elevation in a Real-World Setting

Dec 1, 2016 by in CARDIOLOGY Comments Off on Analysis of the Invasive Strategy Decision in Patients With Acute Coronary Syndrome Without ST-Segment Elevation in a Real-World Setting

Observational studies have reported a marked discrepancy between the risk estimated by scores and the use of an invasive strategy in patients with acute coronary syndromes. The objective is to…

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