After acute coronary syndrome (ACS), long-term dual antiplatelet therapy with acetylsalicylic acid and a P2Y 12 platelet receptor antagonist is the standard of care for secondary prevention. Despite the introduction…
We would like to thank Dr. Gutgesell for reading our manuscript and providing his insightful comments. The primary objectives of our study were to characterize outcomes and resource utilization of all…
Menon et al suggested that administrative databases are suboptimal for the study of “contemporary outcomes, surgical complications, and resource utilization” in hypoplastic left heart syndrome (HLHS), but they offer no data to…
We appreciate the comments and insights from Dr. Manfredini and colleagues and Dr. Deshmukh concerning the determinants and circadian patterns associated with tako-tsubo cardiomyopathy events. Although this condition has been…
Sharkey et al analyzed a cohort of 186 consecutive patients with takotsubo cardiomyopathy (TTC) and 2,975 patients with ST-segment elevation myocardial infarction and identified a circadian pattern with a peak in…
We read the report “Comparison of Circadian Rhythm Patterns in Takotsubo Cardiomyopathy Versus ST-Segment Elevation Myocardial Infarction” by Sharkey et al. The investigators comprehensively evaluated the chronobiologic pattern of the presentation of Takotsubo…
Published reports of randomized clinical trials tend to emphasize the statistical significance of the treatment effect (p values) rather than its magnitude (effect size), although the clinical importance of the…
In 2015, there will be an estimated 11.3 million cancer survivors. With an increasing population of cancer survivors, it is imperative to understand the treatment options available and outcomes for…
The presence of severe atherosclerosis of the ascending aorta, and its extreme form the “porcelain” aorta, is associated with a worse clinical outcome in patients undergoing surgical aortic valve replacement….
In patients with severe mitral regurgitation (MR) referred for cardiac surgery, left atrial (LA) remodeling and enlargement are accompanied by mechanical stress, mediated cellular hypertrophy, and interstitial fibrosis that finally…
