Kawasaki Disease
Chapter 45 Kawasaki Disease David R. Fulton, Jane W. Newburger Kawasaki disease, initially described by Dr. Tomisaku Kawasaki in 1967,1 is an acute systemic vasculitis of uncertain etiology that predominantly…
Giant Cell Arteritis
Chapter 43 Giant Cell Arteritis Maria C. Cid, Peter A. Merkel Giant-cell (temporal) arteritis (GCA) is a chronic inflammatory arteritis that preferentially involves large and medium-sized arteries and affects persons…
The Endothelium
Chapter 2 The Endothelium Jane A. Leopold In 1839, the German physiologist Theodor Schwann became the first to describe a “thin, but distinctly perceptible membrane” that he observed as part…
Pathophysiology of Vasculitis
Chapter 9 Pathophysiology of Vasculitis Peter Libby The pathophysiological mechanisms that underlie vasculitis include elements of virtually all effector limbs of host defenses, including innate and adaptive immunity. Various classification…
Epidemiology and Pathophysiology of Mesenteric Vascular Disease
Chapter 26 Epidemiology and Pathophysiology of Mesenteric Vascular Disease Rachel C. Danczyk, Gregory J. Landry, Gregory L. Moneta Severe acute intestinal ischemia results from sudden symptomatic reduction in intestinal blood…
Pharmacology of Antithrombotic Drugs
Chapter 7 Pharmacology of Antithrombotic Drugs Omar P. Haqqani, Mark D. Iafrati, Jane E. Freedman Atherothrombotic disease and atherosclerotic plaque rupture is the leading cause of death worldwide. Its prevalence…
Venous Thrombosis
Chapter 52 Venous Thrombosis Jeffrey I. Weitz, John W. Eikelboom Definitions Deep vein thrombosis (DVT) refers to an obstruction of a deep vein by thrombus, usually in the legs or…
Acrocyanosis
Chapter 49 Acrocyanosis Veerendra Chadachan, Robert T. Eberhardt The term acrocyanosis is derived from the Greek words akron (meaning “extremity”) and kyanos (meaning “blue”). As a medical condition, acrocyanosis is…
Erythromelalgia
Chapter 50 Erythromelalgia Mark D.P. Davis, Thom W. Rooke Definition and Historical Perspective Erythromelalgia is a rare condition of the extremities characterized by the triad of redness, warmth, and pain….
Pathophysiology of Peripheral Artery Disease, Intermittent Claudication, and Critical Limb Ischemia
Chapter 17 Pathophysiology of Peripheral Artery Disease, Intermittent Claudication, and Critical Limb Ischemia William R. Hiatt, Eric P. Brass Peripheral artery disease (PAD) is a manifestation of systemic atherosclerosis that…
