Cellular and Molecular Pathology of Lung Cancer 3 Edwin R. Parra and Ignacio I. Wistuba INTRODUCTION Traditionally, clinical treatment options for lung cancer were based on the distinction between small…
Management of Thymic Tumors 15 Sukhmani K. Padda, Bryan M. Burt, and Heather A. Wakelee INTRODUCTION Epidemiology Thymic epithelial tumors (TETs), including thymomas and thymic carcinomas, are derived from thymic…
Management of Pulmonary Neuroendocrine Tumors 13 Ying Wang, Cheryl Ho, and Janessa Laskin INTRODUCTION Pulmonary neuroendocrine tumors (NETs) are a spectrum of lung malignancies that arise from the neuroendocrine (NE)…
Management of Elderly and High-Risk Patients With Lung Cancer 12 Vinicius Ernani and Taofeek K. Owonikoko INTRODUCTION Lung cancer is the leading cause of cancer-associated mortality worldwide, causing an estimated…
Biologic Basis of Lung Cancer 2 Charles A. Powell and Vaishnavi Kundel LUNG CARCINOGENESIS Exposure and Susceptibility Tobacco smoking is the major cause of lung cancer (1). Individuals with predisposition…
Management of Pleural Mesothelioma 14 Anish Thomas and Raffit Hassan INTRODUCTION Malignant mesothelioma is an aggressive tumor that arises from the serosal surfaces of pleura, pericardium, peritoneum, or the tunica…
Lung Cancer Screening 4 Steven E. Lommatzsch and James Jett INTRODUCTION Lung cancer is the leading cause of cancer-related death in the United States (1). The association between tobacco use…
Epidemiology and Etiology of Lung Cancer 1 Ann G. Schwartz INCIDENCE AND MORTALITY In 2015, lung cancer was the second most common cancer diagnosed in both men and women in…
Management of Recurrent Non–Small-Cell Lung Cancer 9 Bryan J. Schneider INTRODUCTION The management of recurrent non–small-cell lung cancer (NSCLC) has become more challenging over the past 10 years. Previously, few…
Management of Extensive-Stage Small Cell Lung Cancer 11 Gregory P. Kalemkerian and James A. Hayman INTRODUCTION Small cell lung cancer (SCLC) is an aggressive, poorly differentiated neuroendocrine carcinoma with clinical,…
