Genetic Polymorphisms and the Cardiovascular Risk of Non-Steroidal Anti-Inflammatory Drugs

Dec 23, 2016 by in CARDIOLOGY Comments Off on Genetic Polymorphisms and the Cardiovascular Risk of Non-Steroidal Anti-Inflammatory Drugs

The cardiovascular safety of cyclooxygenase-2–selective (coxibs) and nonselective nonsteroidal anti-inflammatory drugs (NSAIDs) is of concern, although most users remain free of adverse outcomes. A gene-drug interaction could modulate this cardiovascular…

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Comparison of Long-Term (4-Year) Outcomes of Patients With Unprotected Left Main Coronary Artery Narrowing Treated With Drug-Eluting Stents Versus Coronary-Artery Bypass Grafting

Dec 23, 2016 by in CARDIOLOGY Comments Off on Comparison of Long-Term (4-Year) Outcomes of Patients With Unprotected Left Main Coronary Artery Narrowing Treated With Drug-Eluting Stents Versus Coronary-Artery Bypass Grafting

Percutaneous coronary intervention with drug-eluting stents (DES) may achieve midterm outcomes comparable to coronary artery bypass grafting (CABG) for unprotected left main coronary artery disease, but few real-world, long-term studies…

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Comparison of Rates of Progression of Coronary Atherosclerosis in Patients With Diabetes Mellitus Versus Those With the Metabolic Syndrome

Dec 23, 2016 by in CARDIOLOGY Comments Off on Comparison of Rates of Progression of Coronary Atherosclerosis in Patients With Diabetes Mellitus Versus Those With the Metabolic Syndrome

Diabetes mellitus (DM) and metabolic syndrome (MS) are associated with adverse cardiovascular outcomes. However, the extent and progression of coronary atherosclerosis for these conditions have not been directly compared. Three…

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Risk of Adverse Outcomes in Taiwan Associated With Concomitant Use of Clopidogrel and Proton Pump Inhibitors in Patients Who Received Percutaneous Coronary Intervention

Dec 23, 2016 by in CARDIOLOGY Comments Off on Risk of Adverse Outcomes in Taiwan Associated With Concomitant Use of Clopidogrel and Proton Pump Inhibitors in Patients Who Received Percutaneous Coronary Intervention

Recent studies have suggested that proton pump inhibitors (PPIs) might reduce the inhibitory effect of clopidogrel on platelet aggregation, possibly through inhibition of the hepatic cytochrome P450 2C19 (CYP2C19) isoenzyme….

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Angiographic Predictors of Recurrent Stent Thrombosis (from the Outcome of PCI for Stent-ThrombosIs MultIcentre STudy [OPTIMIST])

Dec 23, 2016 by in CARDIOLOGY Comments Off on Angiographic Predictors of Recurrent Stent Thrombosis (from the Outcome of PCI for Stent-ThrombosIs MultIcentre STudy [OPTIMIST])

Stent thrombosis is a catastrophic occurrence burdened by a high mortality rate and a tendency to recur. We sought to evaluate the angiographic risk factors for recurrent stent thrombosis (rST)…

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Clinical and Angiographic Predictors of ST-Segment Recovery After Primary Percutaneous Coronary Intervention

Dec 23, 2016 by in CARDIOLOGY Comments Off on Clinical and Angiographic Predictors of ST-Segment Recovery After Primary Percutaneous Coronary Intervention

Important determinants of incomplete ST-segment recovery in patients undergoing primary percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI) have been incompletely characterized. Early risk stratification could identify patients…

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Comparison of Primary Percutaneous Coronary Intervention in Real-World Populations Versus Clinical Trial Populations

Dec 23, 2016 by in CARDIOLOGY Comments Off on Comparison of Primary Percutaneous Coronary Intervention in Real-World Populations Versus Clinical Trial Populations

The efficacy of primary percutaneous coronary intervention (PPCI) has been documented in several randomized-controlled trials. We sought to examine the clinical outcome after PPCI of real-world patients eligible and ineligible…

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Difference in Patient Profiles and Outcomes in Japanese Versus American Patients Undergoing Coronary Revascularization (Collaborative Study by CREDO-Kyoto and the Texas Heart Institute Research Database)

Dec 23, 2016 by in CARDIOLOGY Comments Off on Difference in Patient Profiles and Outcomes in Japanese Versus American Patients Undergoing Coronary Revascularization (Collaborative Study by CREDO-Kyoto and the Texas Heart Institute Research Database)

Although coronary revascularization is common in both Japan and the United States (US), no direct comparison has been performed to demonstrate differences in the clinical characteristics and long-term outcomes of…

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