Prosthetic Heart Valves



Fig. 21.1
Cardiac auscltation findings for a 60 year old female presenting with chest pain and a history of rheumatic heart disease





  • A loud, crisp mitral closing click and a 2/6 grade murmur was heard from the right upper sternal border to the base of the neck.


  • A crisp mitral opening click was present at the left sternal border, and at the right sternal border it was a grade 1/4 murmur.


  • A normal A2 was present with no mitral diastolic murmur.







    Test Results


    Echocardiogram results:



    • LV ejection fraction 60 %.


    • Mild left atrial enlargement (46 mm).


    • Grade 2 aortic regurgitation with mild valve thickening.


    • Prosthetic mitral valve with peak velocity of 1.3 m/s (Fig. 21.2).

      A310603_1_En_21_Fig2_HTML.gif


      Fig. 21.2
      Echocardiogram of 69 year old female revealing a prosthetic mitral valve with peak velocity of 1.3 m/s




      • Prosthetic closure velocity noted.



    Clinical Basics



    Definitions






    • Prosthetic heart valves are classified as mechanical or biological:

      A.

      Mechanical valves (Fig. 21.3).

      A310603_1_En_21_Fig3_HTML.gif


      Fig. 21.3
      Common mechanical heart valves: (a) Ball in cage design. (b) Bileaflet tilting disc. (c) Tilting disc




      • Primarily made of carbon alloys.


      • Manufactured using industrial materials.


      • Design is bileaflet or tilting disk [1].

       

      B.

      Biological valves.



      • Primarily made of material from living tissue.


      • Includes porcine aortic valves, valves produced from bovine pericardium, homografts (valves from other human beings), and autografts (valves from the patient) [1].

       


    Prevalence of Implanted Valves






    • 60 % carbon alloys with a tilting disk or bileaflet design [1].


    • 40 % bioprosthetic valves [1].


    Complications of Prosthetic Heart Valves






    • Thromboembolism.


    • Infective endocarditis.


    • Valve leaflet failure: uncommon.


    • Late complications include pannus formation with or without valve dysfunction.


    Key Auscultation Features






    • Mechanical valves have auscultation characteristics including.



      • Flow murmurs.



        • Because even normally functioning prosthetic valves have a pressure gradient across them associated with flow acceleration.



          • The “normal” prosthetic valve does not provide a normal valve orifice area:



            • Normal mitral valve area is 4–6 cm2.


            • Prosthetic MVA (depends on type and size):



              • Starr-Edwards Caged Ball (1.4–2.6 cm2).


              • St. Jude Bileaflet (1.0–2.03 cm2).


              • Bjork-Shiley Tilting Disc (1.72–2.2 cm2).


      • Opening and closing sounds created by mechanical valve components.


    • Auscultation examples of prosthetic heart valves.



      • Click here to listen to an example of an auscultation in a patient with aortic valve replacement with a St. Jude valve and view an image of the phonocardiogram (Video 21.1).


      • Click here to listen to examples of several patients with prosthetic valves, as described by Dr. W. Proctor Harvey (Video 21.2).


    Auscultation Differential Diagnosis






    • Mechanical valves produce very audible opening and closing clicks, to the extent of not needing a stethoscope. Many patients with prosthetic valves hear their own valve clicks.


    • Mechanical heart valves have different auscultation sounds that are dependent on the following:



      • Type of valve used.


      • Position of the valve.


      • If the functioning of the valve is normal.


      • In MV mechanical valves, the heart sound sequence simulates mitral stenosis.


      • Basic Features:



        • S1: prosthetic closing click.


        • S2: should be normal.


      • May be followed by opening click.


    • Auscultation differences among prostheses in the mitral valve position (Fig. 21.4); Aortic valve findings are shown in Fig. 21.5.

      A310603_1_En_21_Fig4_HTML.gif


      Fig. 21.4
      Typical cardiac auscultation findings for a variety of common mitral prostheses


      A310603_1_En_21_Fig5_HTML.gif


      Fig. 21.5
      Typical cardiac auscultation findings for a variety of common aortic prostheses




      • Ball-in-cage Valves.



        • With normal valve and ventricular function, the Ball-in-cage valve produces the loudest and most distinguishing opening and closing clicks in any position.


        • A more prominent opening click than closing click.


        • A 2–3/6 systolic ejection murmur is heard.


        • No diastolic murmur is heard.


      • Single Tilting Disc Valves.



        • An opening click in the mitral position is rarely heard.


        • A 2/6 systolic ejection murmur is heard.


        • A 1–2/6 diastolic rumble is typically heard.


      • Porcine Valves.



        • An opening click is audible 50 % of the time.


        • A 1–2/6 apical systolic ejection murmur is heard 50 % of the time.


        • A diastolic rumble 1/2–2/3.


      • Bileaflet Valves.



        • A closing click is very audible while the opening click is typically not heard.


        • Diastolic rumbling murmur may be heard.


    Clinical Clues to the Detection of the Lesion






    • All prosthetic valves have gradients, so murmurs in the forward flow direction are common.



      • Regurgitant murmurs are not expected.


    • Exercising the patient may accentuate a diastolic murmur.



      • Leads to increase in heart rate and blood flow, which increases the gradient, thereby facilitating murmur auscultation.


    • Decrease or disappearance of the prosthetic closing sound may represent development of thrombus or fibrous pannus ingrowth.



      • Closing sound should generally be the loudest sound.


    • A soft diastolic rumble can occur with MV prosthesis.



      • Should not be loud.


      • New diastolic murmur or change may be significant.


    Diagnostic Implications of the Auscultation Features



    Testing for Valve Thrombosis






    • Reduction of opening and closing click could point to thrombosis.


    • Differences in the valve types: mechanical valves tend to have greater problems than biological valves [2].


    • Antithrombotic Therapy.



      • Typically required for mechanical valves but not bioprosthetic valves.


    What Development of New Murmur May Signify






    • Valve dysfunction.



      • Systolic or diastolic murmur.


    • Paravalvular leak.


    Structural Deterioration






    • Mechanical valves can last 20–30 years.


    • 10–20 % human aortic homograft prostheses fail in 10–15 years.


    • 30–35 % porcine heterograft prostheses fail within 10–15 years.
      < div class='tao-gold-member'>

      Only gold members can continue reading. Log In or Register to continue

    Stay updated, free articles. Join our Telegram channel

    Jul 10, 2016 | Posted by in CARDIOLOGY | Comments Off on Prosthetic Heart Valves

    Full access? Get Clinical Tree

    Get Clinical Tree app for offline access