RESPIRATORY

Diffuse Alveolar Hemorrhage in Children

Jul 3, 2019 by in RESPIRATORY Comments Off on Diffuse Alveolar Hemorrhage in Children

Abstract Diffuse alveolar hemorrhage most commonly refers to bleeding from the low-pressure pulmonary vascular bed and is a rare cause of chronic interstitial lung disease in children. Patients can present…

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Chest Wall and Respiratory Muscle Disorders

Jul 3, 2019 by in RESPIRATORY Comments Off on Chest Wall and Respiratory Muscle Disorders

Abstract Disorders of the chest wall, spine, and respiratory muscles include an array of conditions which share respiratory function abnormalities consistent with restrictive lung disease. Depending on the cause, they…

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Laryngeal and Tracheal Airway Disorders

Jul 3, 2019 by in RESPIRATORY Comments Off on Laryngeal and Tracheal Airway Disorders

Abstract Over the past several decades, medical and technologic progress in the care of critically ill infants with extreme prematurity (i.e., gestational age < 28 weeks), multisystem congenital anomalies, airway…

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Pediatric Lung Transplantation

Jul 3, 2019 by in RESPIRATORY Comments Off on Pediatric Lung Transplantation

Abstract Indications for pediatric lung transplantation vary by age, with some conditions leading to transplant throughout childhood (e.g., pulmonary hypertension) and others predominating in younger (e.g., surfactant disorders) or older…

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Gastroesophageal Reflux Disease and Eosinophilic Esophagitis in Children With Complex Airway Disease

Jul 3, 2019 by in RESPIRATORY Comments Off on Gastroesophageal Reflux Disease and Eosinophilic Esophagitis in Children With Complex Airway Disease

Abstract Gastroesophageal reflux disease (GERD), gastrointestinal dysmotility, and Eosinophilic Esophagitis (EoE) are all entities which can affect children with complex airway conditions. GERD is defined as symptoms or mucosal changes…

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Nonpulmonary Manifestations of Cystic Fibrosis

Jul 3, 2019 by in RESPIRATORY Comments Off on Nonpulmonary Manifestations of Cystic Fibrosis

Abstract While lung disease continues to be the main cause of morbidity and mortality, the improved survival rates have meant that nonpulmonary complications have become increasingly important in the care…

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Molecular Therapies for Cystic Fibrosis

Jul 3, 2019 by in RESPIRATORY Comments Off on Molecular Therapies for Cystic Fibrosis

Abstract This chapter describes the therapeutic strategies for cystic fibrosis which are based on targeting cystic fibrosis transmembrane conductance regulator (CFTR), either at the gene or protein level. We provide…

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