Bradycardias (Bradyarrhythmias)

A number of arrhythmias and conduction disturbances associated with a slow heart rate have been described. The term bradycardia (or bradyarrhythmia) refers to arrhythmias and conduction abnormalities that produce a heart rate of less than 60 beats/min. Fortunately, the differential diagnosis of a slow pulse is relatively simple in that only a few causes must be considered. Bradyarrhythmias fall into five general classes (Box 20-1).

Sinus Bradycardia and Related Rhythms

Sinus bradycardia is sinus rhythm with a rate less than 60 beats/min (Fig. 20-1). When 1:1 AV conduction is present, each QRS complex is preceded by a P wave; the P wave is negative in lead aVR and positive in lead II, indicating that the sinoatrial (SA) node is the pacemaker. Some individuals may have sinus bradycardia of 30 to 40 beats/min or less.

Figure 20-1 Marked sinus bradycardia at about 40/min. Sinus arrhythmia is also present. Sinus bradycardia (like sinus tachycardia) always needs to be interpreted in clinical context because it may be a normal variant (due to increased vagal tone in a resting athlete or in a healthy person during sleep) or may be due to drug effect/toxicity, sinus node dysfunction, etc., as discussed in Chapter 13. The PR interval here is also slightly prolonged (0.24 sec), also consistent with increased vagal tone or with certain drugs that depress activity in the SA and AV nodes (e.g., beta blockers).

Sinus bradycardia may be related to a decreased firing rate of the sinus node pacemaker cells or to actual SA block (see Chapter 13). The most extreme example of sinus node dysfunction is SA node arrest (see Chapters 13 and 19). Sinus bradycardia may also be associated with wandering atrial pacemaker (WAP).

Wandering Atrial Pacemaker

Wandering atrial (supraventricular) pacemaker is an arrhythmia that is somewhat difficult to classify. As shown in Figure 20-2, this rhythm is characterized by multiple P waves of varying configuration with a relatively normal or slow heart rate. This pattern reflects shifting of the intrinsic pacemaker between the sinus node and different ectopic atrial sites, and sometimes the area around the AV junction (node).

Figure 20-2 The variability of the P wave configuration in this lead II rhythm strip is caused by shifting of the pacemaker site between the sinus node and ectopic atrial locations.

WAP may be seen in a variety of settings. Occasionally it develops in normal persons (particularly during sleep or states of high vagal tone). It may also occur with certain drug toxicities, sick sinus syndrome, and different types of organic heart disease.

Clinicians should be aware that WAP is quite distinct from multifocal atrial tachycardia (MAT), another arrhythmia with multiple different P waves. In WAP the rate is normal or slow. In MAT it is rapid. For rhythms that resemble MAT (see Chapter 14), but with rates between 60 to 100 beats/min, the more general term multifocal atrial rhythm can be used.

AV Junctional (Nodal) and Ectopic Atrial Rhythms

With a slow AV junctional escape rhythm (Fig. 20-3) either the P waves (seen immediately before or just after the QRS complexes) are retrograde (inverted in lead II and upright in lead aVR), or no P waves are apparent if the atria and ventricles are stimulated simultaneously. Slow heart rates may also be associated with ectopic atrial rhythms, including WAP (see previous discussion).

Figure 20-3 The heart rate is about 43 beats/min. The baseline between the QRS complexes is perfectly flat (i.e., no P waves are evident).

AV Heart Block (Second or Third Degree) or AV Dissociation

A slow ventricular rate of 60 beats/min or less (even as low as 20 beats/min) is the rule with complete heart block because of the slow intrinsic rate of the nodal (junctional) or idioventricular pacemaker (Fig. 20-4). In addition, patients with second-degree block (nodal or infranodal) often have a bradycardia because of the dropped (nonconducted) beats (see Chapter 17).

Figure 20-4 The sinus (P wave) rate is about 80 beats/min. The ventricular (QRS) rate is about 43 beats/min. Because the atria and ventricles are beating independently, the PR intervals are variable. The QRS complex is wide because the ventricles are being paced by an idioventricular pacemaker.

Isorhythmic AV dissociation and related arrhythmias, which may be confused with complete AV heart block, is also frequently associated with a heart rate of less than 60 beats/min (see Chapter 17).

Atrial Fibrillation or Flutter with a Slow Ventricular Rate

Paroxysmal atrial fibrillation (AF), prior to treatment, is generally associated with a rapid ventricular rate. However, the rate may become excessively slow (less than 50 to 60 beats/min) because of drug effects or toxicity (e.g., beta blockers, calcium channel blockers, digoxin) or because of underlying disease of the AV junction (Fig. 20-5). In such cases the ECG shows the characteristic atrial fibrillatory (f) waves with a slow, sometimes regularized ventricular (QRS) rate. The f waves may be very fine and easily overlooked. A very slow, regularized ventricular response in AF suggests the presence of underlying complete AV heart block (see Chapters 15 and 17).

Figure 20-5 Regularization and excessive slowing of the ventricular rate with atrial fibrillation are usually a sign of drug toxicity (especially digitalis) or intrinsic atrioventricular nodal disease (see Chapters 15 and 18)

Tachycardias (Tachyarrhythmias)

At the opposite end of the spectrum from bradyarrhythmias are the tachycardias. These rhythm disturbances produce a heart rate faster than 100 beats/min.

From a clinician’s perspective, the tachyarrhythmias can be most usefully divided into two general groups: those with a “narrow” (normal) QRS duration and those with a “wide” QRS duration (Table 20-1).

TABLE 20-1 Major Tachyarrhythmias: Simplified Classification

^∗ The three most common types of PSVTs are AV nodal reentrant tachycardia (AVNRT), atrioventricular reentrant tachycardia (AVRT) involving a bypass tract, and atrial tachycardia (AT) including unifocal and multifocal atrial tachycardia, as discussed in Chapter 14. Other nonparoxysmal supraventricular tachycardias also may occur, including types of so-called incessant atrial, junctional, and bypass tract tachycardias. (For further details of this advanced topic, see selected references cited in the Bibliography.)

Narrow complex tachycardias are almost invariably supraventricular (i.e., the focus of stimulation is within or above the AV junction). Wide complex tachycardias, by contrast, are either ventricular or supraventricular with aberrant ventricular conduction (i.e., supraventricular tachycardia [SVT] with aberrancy).

The four major classes of supraventricular tachyarrhythmia^∗ are sinus tachycardia, paroxysmal supraventricular tachycardia (PSVT), atrial flutter, and AF. With each class, cardiac activation occurs at one or more sites in the atria or AV junction (node), above the ventricles (hence supraventricular). This activation sequence is in contrast to ventricular tachycardia (VT) in which the depolarization impulses originate in the ventricles. VT is simply a run of three or more consecutive premature ventricular depolarizations (see Chapter 16). The QRS complexes are always wide because the ventricles are not being stimulated simultaneously. The rate of VT is usually between 100 and 200 beats/min. By contrast, with supraventricular arrhythmias the ventricles are stimulated normally (simultaneously), and the QRS complexes are therefore narrow (unless a bundle branch block is also present).