Hypertension in South Asians
Elevated blood pressure (BP) is a growing health problem in South Asia, where it is the second largest risk factor for disability-adjusted life years lost, predominantly because of its strong…
Hypertension in Latin/Hispanic Population
Acknowledgments This work was supported by PI14/01841 grant from Instituto de Salud Carlos III and FONDOS FEDER. The term Hispanic or Latino refers to a person of Cuban, Mexican, Puerto…
Hypertension in East Asians and Native Hawaiians
With the changes in lifestyle and increasing longevity, the prevalence of hypertension increases worldwide. However, several classes of efficacious antihypertensive drugs are readily available for the management of hypertension in…
General Population and Global Cardiovascular Risk Prediction
Systemic arterial hypertension is the condition of persistent, nonphysiologic elevation of systemic blood pressure (BP). It is typically defined as a resting systolic BP (SBP) 140 mm Hg or higher,…
Perioperative Genomics
Abstract Preliminary candidate gene and genome-wide association studies (GWAS) suggest that susceptibility to adverse perioperative events, including cardiac (myocardial infarction, ventricular dysfunction, atrial fibrillation), neurologic, and renal (among others) is…
Cardiovascular Pharmacogenetics
Abstract This chapter will apply the principles and concepts introduced in the “Pharmacogenetics and Pharmacogenomics” chapter in volume 2, namely, discussion of four classes of genetic variants that underlie drug…
Genomics to Predict Risk of Coronary Artery Disease
Abstract It has long been known that there is a heritable component to coronary artery disease (CAD). However, identifying the actual genetic loci influencing CAD risk was not possible prior…
Genomics of Ischemic Stroke and Prospects for Clinical Applications
Abstract Ischemic stroke, which is caused by blockage of vessels supplying blood to the brain, represents approximately 87% of all strokes in the United States. While a significant heritable component…
Arrhythmia Genomics
Abstract Abnormalities of cardiac rhythm are important causes of cardiovascular disability, stroke, and sudden cardiac death. Two general approaches have been used to identify genes playing a role in arrhythmia…
Genetics and Genomics of Peripheral Arterial Disease
Abstract Advances in mouse and human genome research have dramatically altered the landscape and pace of advances in the diagnosis and treatment and many diseases. Peripheral arterial disease (PAD) is…
