Diagnosis and Presentation of Cystic Fibrosis
Abstract Most children with cystic fibrosis (CF) in current times are likely to be picked up through newborn screening programs and confirmed by the finding of two CF-causing mutations and…
The Immunopathogenesis of Asthma
Abstract Asthma occurs as a result of the interplay of genetic susceptibility and environmental influences on the developing lungs and immune system. Asthma in children is predominantly associated with the…
Lung Injury Caused by Pharmacologic Agents
Abstract Numerous drugs can cause pulmonary reactions in children. Chemotherapeutic agents are most frequently implicated, although toxic effects of other medications have been recognized. Reactions to chemotherapeutic agents may be…
Wheezing in Older Children: Asthma
Abstract Asthma is the most common cause of wheezing in school age children and adolescents. An inflammatory condition characterized by variable, reversible airway obstruction and hyperreactivity, asthma is a complex,…
Tuberculosis
Abstract Tuberculosis, caused by Mycobacterium tuberculosis, is the leading infectious cause of death worldwide; it is characterized by unique clinical stages. Adults with contagious forms of tuberculosis transmit the organism…
The Epidemiology of Asthma
Abstract Epidemiology is the study of populations to discover modifiable factors that contribute to disease occurrence and natural history with a view to reducing disease burden through prevention. Asthma is…
New Concepts in Children’s Interstitial and Diffuse Lung Disease
Abstract Children with diffuse and interstitial lung disease (chILD) comprise a group of rare disorders with significant morbidity and mortality. Individually these disorders are rare but collectively they create a…
The Influence of Upper Airway Disease on the Lower Airway
Abstract Upper airway disease, including chronic rhinitis and rhinosinusitis, affect most children with asthma. Over the past two decades, our understanding of the connection between the nose, paranasal sinuses, and…
Modern Molecular Therapies for Application in Managing Childhood Asthma
Abstract Focus on drug development for asthma has been on development of immunomodulator therapies, with the hopes that they can eventually alter the natural course of asthma. This review focuses…
Severe Asthma
Abstract Most pediatric asthma is easily treated with low-dose inhaled corticosteroids, occasionally combined with a long-acting bronchodilator, provided the medications are administered regularly and correctly. If the child does not…
