A pragmatic individually randomized trial to evaluate the effectiveness of high-dose vs standard-dose influenza vaccine in older adults: Rationale and design of the DANFLU-2 trial

Jun 27, 2026 by in CARDIOLOGY Comments Off on A pragmatic individually randomized trial to evaluate the effectiveness of high-dose vs standard-dose influenza vaccine in older adults: Rationale and design of the DANFLU-2 trial
Highlights • High-dose influenza vaccine reduces laboratory-confirmed influenza, but its effectiveness against severe cardio-respiratory outcomes in the older general population has not been assessed in a fully powered, individually randomized…
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Rationale and design of the comparative effectiveness of ICD vs non-ICD therapy in contemporary heart failure patients at a low risk for arrhythmic death (CONTEMP-ICD) trial

Jun 27, 2026 by in CARDIOLOGY Comments Off on Rationale and design of the comparative effectiveness of ICD vs non-ICD therapy in contemporary heart failure patients at a low risk for arrhythmic death (CONTEMP-ICD) trial
ABSTRACT Background Current recommendations for a prophylactic (primary prevention) implantable cardioverter defibrillator (ICD) in patients with both ischemic and nonischemic heart failure with reduced ejection fraction (HFrEF) originate from clinical…
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Rationale and design of European microcirculatory resistance and absolute flow team: The Euro-CRAFT registry

Jun 27, 2026 by in CARDIOLOGY Comments Off on Rationale and design of European microcirculatory resistance and absolute flow team: The Euro-CRAFT registry
Highlights • CMD is a key pathophysiological mechanism underlying ANOCA. • The precision and reproducibility of bolus thermodilution remain limited. • MRR is a novel index for evaluating coronary microvascular…
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DAPAgliflozin for renal protection in heart transplant recipients. Rationale and design of the randomized controlled DAPARHT trial

Jun 27, 2026 by in CARDIOLOGY Comments Off on DAPAgliflozin for renal protection in heart transplant recipients. Rationale and design of the randomized controlled DAPARHT trial
ABSTRACT Background and aims Heart transplantation is the preferred treatment for selected patients with end stage heart failure. Kidney function often declines after heart transplantation. Sodium-glucose cotransporter 2 inhibitors (SGLT2i)…
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Distal versus conventional transradial artery access for coronary catheterization in patients with STEMI (DR-STEMI): Rationale and design of an international, multicenter, randomized trial

Jun 27, 2026 by in CARDIOLOGY Comments Off on Distal versus conventional transradial artery access for coronary catheterization in patients with STEMI (DR-STEMI): Rationale and design of an international, multicenter, randomized trial
Highlights • First international RCT comparing dTRA vs TRA in STEMI for needle-to-wire time. • Noninferiority trial with 554 patients evaluating procedural efficiency. • Secondary outcomes: radial artery occlusion and…
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PRevention of sudden cardiac death aFter myocardial infarction by defibrillator implantation: Design and rationale of the PROFID EHRA randomized clinical trial

Jun 27, 2026 by in CARDIOLOGY Comments Off on PRevention of sudden cardiac death aFter myocardial infarction by defibrillator implantation: Design and rationale of the PROFID EHRA randomized clinical trial
Highlights • A minority of post-MI patients with LVEF ≤ 35% ever need their primary prevention ICD. • Pharmacotherapy has advanced since previous trials for primary prevention ICD. • This…
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IMpact of therapY using coleSevelam treatment reducing bile acids in patients with fonTan cIrCulation (MYSTIC): Rationale and study design

Jun 27, 2026 by in CARDIOLOGY Comments Off on IMpact of therapY using coleSevelam treatment reducing bile acids in patients with fonTan cIrCulation (MYSTIC): Rationale and study design
ABSTRACT Rationale Patients with a Fontan circulation suffer from progressive multiorgan dysfunction, yet central biochemical drivers remain poorly defined. Our recent work exploring metabolomic analyses have identified- elevated circulating bile…
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Selective C-reactive protein apheresis in ST-elevation myocardial infarction: Design and rationale of the randomized CRP-STEMI trial

Jun 27, 2026 by in CARDIOLOGY Comments Off on Selective C-reactive protein apheresis in ST-elevation myocardial infarction: Design and rationale of the randomized CRP-STEMI trial
Highlights • CRP-STEMI is an investigator-initiated, randomized, open-label, multicenter trial. • A total of 202 STEMI patients with elevated CRP post PCI enrolled at 5 centers. • The intervention group…
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A pragmatic individually randomized trial to evaluate bivalent RSV prefusion F protein–based vaccine effectiveness for preventing RSV hospitalizations in adults aged 60 years or above (DAN-RSV): Rationale and trial design

Jun 27, 2026 by in CARDIOLOGY Comments Off on A pragmatic individually randomized trial to evaluate bivalent RSV prefusion F protein–based vaccine effectiveness for preventing RSV hospitalizations in adults aged 60 years or above (DAN-RSV): Rationale and trial design
ABSTRACT Background Respiratory syncytial virus (RSV) can cause serious illness in older adults and those with chronic conditions. While the bivalent RSVpreF vaccine has been shown to protect against RSV-related…
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Democracy, healthcare, and the public good

Jun 27, 2026 by in CARDIOLOGY Comments Off on Democracy, healthcare, and the public good
“Governments are instituted among Men, deriving their just powers from the consent of the governed.” Thomas Jefferson June 11, 1776, The foundations of democracy and public welfare in the United…
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