Response to letter by Hu regarding article, “Statistical Methodological Limitations and Improvement Suggestions in the Study of Vitamin D Deficiency and Cardiovascular Mortality After Heart Transplantation.”

Jun 27, 2026 by in CARDIOLOGY Comments Off on Response to letter by Hu regarding article, “Statistical Methodological Limitations and Improvement Suggestions in the Study of Vitamin D Deficiency and Cardiovascular Mortality After Heart Transplantation.”
We are writing in response to Hu and Wang’s letter, titled “Statistical Methodological Limitations and Improvement Suggestions in the Study of Vitamin D Deficiency and Cardiovascular Mortality After Heart Transplantation,”…
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Medicare coverage gap status, adherence to oral anticoagulation, and stroke rates in patients with atrial fibrillation

Jun 27, 2026 by in CARDIOLOGY Comments Off on Medicare coverage gap status, adherence to oral anticoagulation, and stroke rates in patients with atrial fibrillation
Highlights • Medicare Part D included a coverage gap during which beneficiaries were responsible for substantially higher portions of medication costs, although the impact of this on oral anticoagulant prescription…
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Statistical methodological limitations and improvement suggestions in the study of vitamin D deficiency and cardiovascular mortality after heart transplantation

Jun 27, 2026 by in CARDIOLOGY Comments Off on Statistical methodological limitations and improvement suggestions in the study of vitamin D deficiency and cardiovascular mortality after heart transplantation
Highlights • Low EPV (4.9) risks unstable Cox model hazard ratios with 14 covariates. • CAV mediation (26.5%) lacks robustness from limited event numbers. • Penalized regression and sensitivity analyses…
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Response to letter by Naeem regarding article, “Loop and thiazide diuretics and outcomes in heart failure with preserved ejection fraction”

Jun 27, 2026 by in CARDIOLOGY Comments Off on Response to letter by Naeem regarding article, “Loop and thiazide diuretics and outcomes in heart failure with preserved ejection fraction”
We thank Drs Qadir and Naeem for their insightful comments. We studied 1765 patients in the Americas cohort of TOPCAT, a randomized trial of spironolactone vs. placebo in patients with…
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Design and rationale of a randomized clinical trial assessing the effect of inclisiran on atherosclerotic plaque in individuals without previous cardiovascular event and without flow- limiting lesions identified in an in-hospital screening: The VICTORION-PLAQUE primary prevention trial

Jun 27, 2026 by in CARDIOLOGY Comments Off on Design and rationale of a randomized clinical trial assessing the effect of inclisiran on atherosclerotic plaque in individuals without previous cardiovascular event and without flow- limiting lesions identified in an in-hospital screening: The VICTORION-PLAQUE primary prevention trial
Highlights • This randomized, double-blind, placebo-controlled Phase 3B trial will evaluate the efficacy of inclisiran, in addition to maximally tolerated statins with or without other lipid-lowering therapies (LLT), in reducing…
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Effect of cerebral embolic protection device on new cerebral embolism during transcatheter aortic valve replacement: A prospective sentinel registry

Jun 27, 2026 by in CARDIOLOGY Comments Off on Effect of cerebral embolic protection device on new cerebral embolism during transcatheter aortic valve replacement: A prospective sentinel registry
Highlights • Cerebral embolic protection (CEP) devices have the potential to reduce embolic burden to the cerebral circulation during transcatheter aortic valve replacement (TAVR); however, their effectiveness in real-world patients…
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Relationship between industry payments to physicians and prescription patterns for PCSK9is, ARNis and DOACs: A report from the NCDR PINNACLE registry

Jun 27, 2026 by in CARDIOLOGY Comments Off on Relationship between industry payments to physicians and prescription patterns for PCSK9is, ARNis and DOACs: A report from the NCDR PINNACLE registry
ABSTRACT Background We examined the association of industry payments to physicians and prescriptions for proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors, angiotensin receptor-neprilysin inhibitor (ARNi), and direct oral anticoagulants (DOAC)….
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