Introduction Clinical outcomes after acute coronary syndrome (ACS) have significantly improved over time. A significant proportion of the reduction in mortality has been the result of development and adoption of…
Introduction The term “reperfusion injury” refers to cellular damage that occurs during the reperfusion phase after an episode of ischemia. If reperfusion occurs after a short period of ischemia, all…
Introduction Despite improvements in secondary preventive care and risk factor modification, there is a persistently elevated risk of recurrent cardiovascular (CV) events after experiencing a myocardial infarction (MI), with more…
Acknowledgments This work was supported in part by NIH grants P01 HL-78825 and UM1 HL-113530 (CCTRN). Introduction Cell-based therapy is an exciting new treatment modality that has the potential to…
Introduction A non–ST-elevation acute coronary syndrome (NSTE-ACS) is caused by a severe flow-limiting stenosis or acute thrombotic obstruction of a coronary artery (see Chapter 13 ). In the absolute majority…
Introduction Atherosclerotic plaque rupture followed by arterial thrombosis is the major determinant that leads to an acute coronary syndrome (ACS). Platelet adhesion, activation, and aggregation have a pivotal role in…
Introduction Myocardial infarction (MI) includes patients presenting with ST-elevation MI (STEMI) and those without ST-segment MI (NSTEMI), and although these types of MI share a common physiopathology and principles of…
Case Vignette A 56-year-old riverboat captain experienced sudden onset of shortness of breath and diaphoresis at 1:30 am while on his boat near Red Wing, Minnesota ( Figure 5-e1 )….
Case Presentation A 57-year-old man presents to a community hospital without capability for primary percutaneous coronary intervention (PPCI) in the early morning (4 am ) with a 1.5-hour history of…
Introduction Cardiac troponin (cTn) is the preferred biomarker for the evaluation of patients with suspected acute myocardial infarction (MI) (see Chapter 7 ). In addition, it makes sense that other…
