Rationale and design of a pragmatic randomized clinical trial assessing a smartphone-based digital health intervention in hypertension: The ELFIE-HYPERTENSION trial

Jun 27, 2026 by in CARDIOLOGY Comments Off on Rationale and design of a pragmatic randomized clinical trial assessing a smartphone-based digital health intervention in hypertension: The ELFIE-HYPERTENSION trial
HIGHLIGHTS • There are limited data on the value of digital health interventions. • Elfie is a free app with a set of features for hypertension management. • Elfie is…
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Design and rationale of a multicenter paramedic randomized trial of noradrenaline versus adrenaline in the initial management of patients with cardiogenic shock—The PANDA trial

Jun 27, 2026 by in CARDIOLOGY Comments Off on Design and rationale of a multicenter paramedic randomized trial of noradrenaline versus adrenaline in the initial management of patients with cardiogenic shock—The PANDA trial
ABSTRACT Background Vasoactive medications constitute an integral component of the hemodynamic support strategy in patients with cardiogenic shock (CS). However, there is an emerging signal of harm associated with the…
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Design and rationale of RECOVER-AUTONOMIC: A randomized platform trial evaluating interventions for Long COVID postural orthostatic tachycardia syndrome

Jun 27, 2026 by in CARDIOLOGY Comments Off on Design and rationale of RECOVER-AUTONOMIC: A randomized platform trial evaluating interventions for Long COVID postural orthostatic tachycardia syndrome
Highlights • NIH-sponsored platform RCT in Long COVID postural orthostatic tachycardia syndrome. • Tests intravenous immunoglobulin and ivabradine vs placebo. • Factorial design includes coordinated care vs usual care. •…
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Association between atherosclerosis and atrial fibrillation progression in patients with paroxysmal atrial fibrillation: Data from the RACE V study

Jun 27, 2026 by in CARDIOLOGY Comments Off on Association between atherosclerosis and atrial fibrillation progression in patients with paroxysmal atrial fibrillation: Data from the RACE V study
Highlights • Atherosclerosis was present in two-thirds of patients with paroxysmal AF, mostly subclinical. • Patients with atherosclerosis had an increased risk of AF progression. • Atherosclerosis remained a determinant…
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Probabilities of treatment effects in complete or culprit-only revascularization for NSTEMI: A Bayesian re-analysis of the SLIM trial

Jun 27, 2026 by in CARDIOLOGY Comments Off on Probabilities of treatment effects in complete or culprit-only revascularization for NSTEMI: A Bayesian re-analysis of the SLIM trial
Highlights • Bayesian re-analysis quantifies treatment effects beyond P -values. • Complete revascularization shows 91% probability of clinically relevant benefit. • Benefit driven by fewer repeat revascularizations and non-fatal myocardial…
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Left Atrial Appendage Occlusion Versus NOACs in patients With Atrial Fibrillation: Rationale and Design of the CATALYST Trial

Jun 27, 2026 by in CARDIOLOGY Comments Off on Left Atrial Appendage Occlusion Versus NOACs in patients With Atrial Fibrillation: Rationale and Design of the CATALYST Trial
Highlights • CATALYST compares Amulet LAAO vs. NOACs in AF patients at elevated stroke risk. • Three co-primary endpoints assess stroke, systemic embolism, CV death, and bleeding. • Post-LAAO care…
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Safety of a remote disease management program to improve sodium-glucose cotransporter-2 inhibitors and glucagon-like peptide-1 receptor agonists prescribing in type 2 diabetes with elevated cardiovascular or kidney risk

Jun 27, 2026 by in CARDIOLOGY Comments Off on Safety of a remote disease management program to improve sodium-glucose cotransporter-2 inhibitors and glucagon-like peptide-1 receptor agonists prescribing in type 2 diabetes with elevated cardiovascular or kidney risk
Highlights • Remote pharmacist-led care safely initiated SGLT2i and GLP1 RA in high-risk T2D. • AE rates matched clinical trials: 29% for SGLT2i, 55% for GLP1 RA initiators. • Only…
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Associations between practice-level compliance with cardiac performance measures and clinical outcomes in US cardiovascular ambulatory care

Jun 27, 2026 by in CARDIOLOGY Comments Off on Associations between practice-level compliance with cardiac performance measures and clinical outcomes in US cardiovascular ambulatory care
Clinical question: Is practice-level compliance with cardiac performance measures associated with clinical outcomes in ambulatory care? Main findings: Heart failure composite and individual performance measure compliance related to beta-blocker and…
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STrategies for antithrombotic tRreatment following transcatheter edge-to-edge repair in patients with severe mitral regurgitation: Rationale and design of STAR-TEER trial

Jun 27, 2026 by in CARDIOLOGY Comments Off on STrategies for antithrombotic tRreatment following transcatheter edge-to-edge repair in patients with severe mitral regurgitation: Rationale and design of STAR-TEER trial
Highlights • Antithrombotic therapy following transcatheter edge-to-edge repair is essential to mitigate ischemic complications, whereas no randomized controlled trial has established the optimal anticoagulation strategies. • STAR-TEER trial is an…
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