Principles of Clinical Pharmacology
Chapter 12 Principles of Clinical Pharmacology Jacques Turgeon, Paul Dorian Most antiarrhythmic drugs are administered in a relatively fixed dose, without taking into account the many sources of variability in…
Genetic Diseases: Short QT Syndrome
Chapter 64 Genetic Diseases Short QT Syndrome N.A. Mark Estes, III, Nathan Van Houzen Short QT syndrome (SQTS) was recently recognized as a familial clinical electrocardiographic entity characterized by ion…
Postoperative Arrhythmias After Cardiac Surgery
Chapter 60 Postoperative Arrhythmias After Cardiac Surgery David B. Bharucha, Babak Bozorgnia, Peter R. Kowey Arrhythmias occur frequently after cardiac surgery. This chapter discusses postoperative atrial and ventricular tachyarrhythmias as…
Mechanisms of Re-entrant Arrhythmias
Chapter 4 Mechanisms of Re-entrant Arrhythmias Sami F. Noujaim, José Jalife The most deadly cardiac arrhythmias result from re-entry, that is, electrical waves that rotate at a high frequency, in…
Evaluation and Management of Arrhythmias Associated with Congestive Heart Failure
Chapter 56 Evaluation and Management of Arrhythmias Associated with Congestive Heart Failure Steven Singh Introduction Heart failure is characterized by a failure to pump an adequate volume of blood to…
Principles of Clinical Trials
Chapter 19 Principles of Clinical Trials Ruth McBride, April Slee Introduction A clinical trial is a medical study in humans. Typically, these studies are conducted to determine the efficacy and…
Disorders of Intracellular Transport and Intercellular Conduction
Chapter 8 Disorders of Intracellular Transport and Intercellular Conduction Andrew L. Wit, Heather S. Duffy Disorders of Intercellular Trafficking The cardiac action potential is formed by stringent coordination of ion…
Autonomic Nervous System and Cardiac Arrhythmias
Chapter 5 Autonomic Nervous System and Cardiac Arrhythmias David G. Benditt, Scott Sakaguchi, J. Gert van Dijk The autonomic nervous system (ANS) comprises the portion of the central nervous system…
Ion Channelopathies: Mechanisms and Genotype-Phenotype Correlations
Chapter 7 Ion Channelopathies Mechanisms and Genotype-Phenotype Correlations Charles Antzelevitch, Jonathan M. Cordeiro Recent years have witnessed an explosion of knowledge contributing to the understanding of ion channelopathies associated with…
