Lymphangioleiomyomatosis
Fig. 17.1 Schematic representation of the mTOR pathway. Tuberin is phosphorylated by multiple inputs from growth signals via growth factors or as a consequence of change in cellular energy status….
Non-langerhans Cell Histiocytosis-Including Erdheim-Chester Disease- and the Lung
Histiocytic disorder Morphology Immunophenotype Reactive histiocytic conditions Non-specific interstitial pneumonitis Polymorphous infiltrate containing macrophages Bronchiolar obstruction Foamy cells Healing process Infections Mycobacteria infections Foamy histiocytes PAS+/Ziehl+ Whipple disease Foamy histiocytes…
Allergic Bronchopulmonary Mycosis
Infectious diseases Invasive aspergillosis Chronic necrotising pulmonary aspergillosis/Aspergilloma Hypersensitivity diseases Aspergillus sensitisation in asthma And severe asthma associated with fungal sensitization (SAFS) Hypersensitivity pneumonitis Allergic bronchopulmonary aspergillosis Aspergillus: An Ubiquitous…
Pulmonary Fibrosis and the Many Faces of UIP
HRCT technical requirements Scans without contrast Full inspiration without respiratory motion Contiguous or noncontiguous axial scans with thin sections, reconstructed at ≤2 cm intervals Reconstructed slice collimation ≤2 mm High…
Chronic Beryllium Disease and Other Interstitial Lung Diseases of Occupational Origin
Clinical findings CBD Sarcoidosis Onset Insidious Acute or insidious Restrictive lung disease Yes Yes Obstructive lung disease Frequent Yes Reduced diffusion capacity Yes Yes Erythema nodosum No Yes Lupus pernio…
Pulmonary Alveolar Microlithiasis
Fig. 20.1 Cases of pulmonary alveolar microlithiasis in the international literature: subdivision by continent (656 pts. out of 670) Table 20.1 Cases of pulmonary alveolar microlithiasis from 56 countries Algeria…
Rare and Emergent Drug-Induced and Iatrogenic Respiratory Conditions: A Guide to Their Recognition and Management
Pattern of DI involvement Typical timing to onset Develops in Typical drugs or compoundsa Main complications Angioedema and UAO Immediate-to-late min-h ACEI, ARB UAO, throat closure, locked airway, asphyxia Anaphylaxis…
Rare Causes and the Spectrum of Hypersensitivity Pneumonitis
Type 1 HP (e.g., farmer’s lung) Type 2 HP (e.g., bird fancier-s lung) Exposure Usually massive and intermittent Usually chronic insidious Usually microorganisms (fungi and actinomycetes) Usually lowdose of…
Interstitial Lung Disease in Undifferentiated Forms of Connective Tissue Disease
Fig. 27.1 High resolution computed tomographic image demonstrating bilateral, peripheral predominant ground glass opacifications suggestive of non-specific interstitial pneumonia Does this patient have connective tissue disease-associated interstitial lung disease? Introduction…
Orphan Tracheopathies
Fig. 6.1 The flow volume loop in fixed central airway obstruction reveals blunting of both the inspiratory and expiratory portions of the loop Conventional chest X-rays are neither sensitive nor…
