Approach to Diffuse Lung Diseases
and Alessandra Cancellieri2 (1) Department of Radiology, Bellaria Hospital, Bologna, Italy (2) Department of Pathology, Maggiore Hospital, Bologna, Italy Clinical features Micaela Romagnoli Rocco Trisolini Pathology Alessandra Cancellieri …
Neuronal Imaging, Ventricular Arrhythmias, and Device Therapy in Heart Failure
and Myron C. Gerson1 (1) University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH 45267, USA KeywordsSudden cardiac deathImplantable cardiac defibrillatorCardiomyopathy 123I-MIBG 11C-HEDHeart failure Since the 1970s, cardiovascular mortality has decreased significantly…
Neural Control of Cardiac Function in Health and Disease
Figure 2-1. Hierarchy for cardiac autonomic control. Autonomic control of cardiac function is mediated by a series of interacting feedback loops from the level of the heart [2] to that…
Dysautonomia: From the Brain Disorders to Neuropathies and Including Diabetes
Synucleinopathies Lewy body disorders Parkinson disease Primary motor disease with parkinsonism and frequent peripheral autonomic neuropathy, orthostatic hypotension, and dementia Dementia with Lewy bodies Rapidly progressive dementia with frequent peripheral…
Neuronal Imaging in Heart Failure
Figure 4-1. (a) Norepinephrine (NE) cascade from synthesis to vesicular storage, release into synaptic cleft, reuptake, and partial inactivation. (b, c) The processes of synthesis, vesicular–axoplasmic exchange, metabolism, release, neuronal…
Chemistry and Biology of Radiotracers Designed to Target Changes in the Myocardial Sympathetic and Parasympathetic Nervous Systems as a Function of Disease or Treatment
Figure 3-1. Although Otto Loewi discovered chemical transmission of nerve impulses using acetylcholine [1], it was von Euler who discovered in 1946 that the true agent of sympathetic transmission is…
PET Imaging and Quantitation of Cardiac Innervation
Nerve Radiotracer Description Sympathetic Presynaptic 11C-hydroxyephedrine (HED) Most widely used PET-based radiotracer for cardiac sympathetic innervation NE analogue, accumulates through NET and transported to storage vesicles by VMAT2 Not metabolized…
Neuronal Imaging and Reverse Remodeling
β-Blockers Angiotensin-converting enzyme inhibitors Angiotensin receptor blockers Aldosterone inhibitors Cell transplantation Coronary arterial revascularization Mitral valve repair/replacement CRT LVAD Inhibition of the β-adrenergic system or renin–angiotensin–aldosterone system (RAAS) is known…
