Acknowledgments The authors’ research was supported by grants from the National Heart, Lung and Blood Institute (PO1 HL51971), National Institute of General Medical Sciences (P20 GM104357), National Institute of Diabetes…
Hypertension genetics is of interest to different health care professionals: The clinician is often embarrassed by patient questioning on the origins of the blood pressure (BP) elevation in the absence…
Elevated blood pressure (BP) is a growing health problem in South Asia, where it is the second largest risk factor for disability-adjusted life years lost, predominantly because of its strong…
Acknowledgments This work was supported by PI14/01841 grant from Instituto de Salud Carlos III and FONDOS FEDER. The term Hispanic or Latino refers to a person of Cuban, Mexican, Puerto…
With the changes in lifestyle and increasing longevity, the prevalence of hypertension increases worldwide. However, several classes of efficacious antihypertensive drugs are readily available for the management of hypertension in…
Systemic arterial hypertension is the condition of persistent, nonphysiologic elevation of systemic blood pressure (BP). It is typically defined as a resting systolic BP (SBP) 140 mm Hg or higher,…
Abstract Preliminary candidate gene and genome-wide association studies (GWAS) suggest that susceptibility to adverse perioperative events, including cardiac (myocardial infarction, ventricular dysfunction, atrial fibrillation), neurologic, and renal (among others) is…
Abstract This chapter will apply the principles and concepts introduced in the “Pharmacogenetics and Pharmacogenomics” chapter in volume 2, namely, discussion of four classes of genetic variants that underlie drug…
Abstract It has long been known that there is a heritable component to coronary artery disease (CAD). However, identifying the actual genetic loci influencing CAD risk was not possible prior…
Abstract Ischemic stroke, which is caused by blockage of vessels supplying blood to the brain, represents approximately 87% of all strokes in the United States. While a significant heritable component…
