Histiocytic and Dendritic Cell Neoplasms (Histiocytic Sarcoma, Tumors Derived from Langerhans Cells, Interdigitating Dendritic Cell Sarcoma, Follicular Dendritic Cell Sarcoma) Borislav A. Alexiev, M.D. Rima Koka, M.D., Ph.D. Follicular Dendritic…
Hodgkin Lymphoma Borislav A. Alexiev, M.D. Rima Koka, M.D., Ph.D. Terminology Hodgkin lymphoma (HL) is a monoclonal lymphoid neoplasm (in most instances derived from B cells) composed of mononuclear Hodgkin…
Precursor T-Cell Lymphoblastic Lymphoma/Leukemia Borislav A. Alexiev, M.D. Rima Koka, M.D., Ph.D. Terminology Precursor T-lymphoblastic lymphoma/leukemia is a neoplasm of lymphoblasts committed to the T-cell lineage, typically composed of small…
Thymic Extranodal Marginal Zone B-Cell Lymphoma of Mucosa-Associated Lymphoid Tissue Borislav A. Alexiev, M.D. Rima Koka, M.D., Ph.D. Terminology Primary thymic extranodal marginal zone B-cell lymphoma (MZBL) of mucosa-associated lymphoid…
Primary Mediastinal Large B-Cell Lymphoma Borislav A. Alexiev, M.D. Rima Koka, M.D., Ph.D. Terminology Primary lymphomas of the mediastinum are believed to arise from mediastinal lymph nodes or, when in…
Mediastinal Germ Cell Tumor with Somatic-Type and Hematologic Malignancy Borislav A. Alexiev, M.D. Allen P. Burke, M.D. Terminology Germ cell tumor with somatic-type malignancy (GCT-STM) denotes a GCT containing a…
Mixed Germ Cell Tumors Borislav A. Alexiev, M.D. Allen P. Burke, M.D. Background Mixed germ cell tumors (GCT) are composed of more than one type of GCT element and are…
Choriocarcinoma Borislav A. Alexiev, M.D. Fabio R. Tavora, M.D., Ph.D. Allen P. Burke, M.D. Terminology Choriocarcinoma is a highly malignant neoplasm composed of syncytiotrophoblasts, cytotrophoblasts, and variably intermediate trophoblast cells….
Embryonal Carcinoma Borislav A. Alexiev, M.D. Anja C. Roden, M.D. Background Mediastinal embryonal carcinoma is a germ cell tumor composed of large primitive cells of epithelial appearance with abundant clear…
Yolk Sac Tumor (Endodermal Sinus Tumor) Borislav A. Alexiev, M.D. Anja C. Roden, M.D. Terminology Mediastinal yolk sac tumor (YST) is a neoplasm characterized by numerous patterns that recapitulate the…
