Congenital Heart Disease
Congenital Heart Disease Allen P. Burke, M.D. Joseph J. Maleszewski, M.D. General Epidemiology Congenital abnormalities of the heart and aortic arch (excluding the congenitally bicuspid aortic valve) occur in slightly…
Sudden Cardiac Death
Sudden Cardiac Death Allen P. Burke, M.D. Joseph J. Maleszewski, M.D. Definition Sudden cardiac death (SCD) is an unexpected death due to cardiac causes occurring in a short time period…
Myocardial Response to Injury
Myocardial Response to Injury Allen P. Burke, M.D. Fabio R. Tavora, M.D., Ph.D. General Myocyte injury results from a variety of insults, including ischemia, inflammation, toxic insults, and physical forces…
Examination of Cardiovascular Specimens
Examination of Cardiovascular Specimens Joseph J. Maleszewski, M.D. Allen P. Burke, M.D. Overview Cardiac specimens may be procured for examination either at autopsy or surgery. Autopsy-derived specimens are in the…
Miscellaneous Mediastinal Tumors (Paraganglioma, Vascular and Lipomatous Tumors, Other Sarcomas)
Miscellaneous Mediastinal Tumors (Paraganglioma, Vascular and Lipomatous Tumors, Other Sarcomas) Borislav A. Alexiev, M.D. Jennifer M. Boland, M.D. Paraganglioma Terminology Paragangliomas are neuroendocrine tumors that arise in the extraadrenal sympathetic…
Synovial Sarcoma
Synovial Sarcoma Borislav A. Alexiev, M.D. Jennifer M. Boland, M.D. Allen P. Burke, M.D. Terminology Synovial sarcoma is a malignant mesenchymal tumor that displays a variable degree of epithelial differentiation,…
Neuroblastoma, Ganglioneuroblastoma, and Ganglioneuroma of the Mediastinum
Neuroblastoma, Ganglioneuroblastoma, and Ganglioneuroma of the Mediastinum Borislav A. Alexiev, M.D. Jennifer M. Boland, M.D. Allen P. Burke, M.D. Introduction Neural tumors constitute 15% of mediastinal tumors in adults, and…
Mediastinal Nerve Sheath Tumors (Schwannoma, Neurofibroma, Malignant Peripheral Nerve Sheath Tumor)
Mediastinal Nerve Sheath Tumors (Schwannoma, Neurofibroma, Malignant Peripheral Nerve Sheath Tumor) Borislav A. Alexiev, M.D. Jennifer M. Boland, M.D. General Peripheral nerve sheath tumors encompass a spectrum of well-defined clinicopathologic…
Mediastinal Gray Zone Lymphoma (B-Cell Lymphoma, Unclassifiable, with Features Intermediate Between Diffuse Large B-Cell Lymphoma and Classical Hodgkin Lymphoma)
Mediastinal Gray Zone Lymphoma (B-Cell Lymphoma, Unclassifiable, with Features Intermediate Between Diffuse Large B-Cell Lymphoma and Classical Hodgkin Lymphoma) Borislav A. Alexiev, M.D. Rima Koka, M.D., Ph.D. Terminology Mediastinal gray…
Anaplastic Large Cell Lymphoma (ALK-Positive and ALK-Negative)
Anaplastic Large Cell Lymphoma (ALK-Positive and ALK-Negative) Borislav A. Alexiev, M.D. Rima Koka, M.D., Ph.D. Background ALK-positive anaplastic large cell lymphoma (ALCL) is a T-cell lymphoma that is characterized by…
