Myocardial Infarction
Myocardial Infarction Allen P. Burke, M.D. Fabio R. Tavora, M.D., Ph.D. Types of Acute Infarcts Acute myocardial infarction indicates irreversible myocardial injury resulting in coagulative necrosis of the myocardium. Ischemia…
Coronary Atherosclerosis
Coronary Atherosclerosis Allen P. Burke, M.D. Fabio R. Tavora, M.D., Ph.D. Methods of Sampling The practicing pathologist will encounter coronary atherosclerosis primarily at autopsy. Because of the high prevalence of…
Cardiac Sarcoidosis
Cardiac Sarcoidosis Fabio R. Tavora, M.D., Ph.D. Allen P. Burke, M.D. Epidemiology The prevalence of sarcoidosis is difficult to ascertain, because many patients are asymptomatic, and the clinical symptoms and…
Cardiac Amyloidosis
Cardiac Amyloidosis Joseph J. Maleszewski, M.D. Allen P. Burke, M.D. Introduction General Amyloidosis is the deposition of misfolded protein with an antiparallel β-pleated sheet configuration in a variety of organs…
Cardiac Involvement in Rheumatologic Diseases
Cardiac Involvement in Rheumatologic Diseases Allen P. Burke, M.D. Fabio R. Tavora, M.D., Ph.D. Acute Rheumatic Carditis Incidence and Epidemiology Acute rheumatic carditis is a common sequela of acute rheumatic…
Cardiac Disease in Hematologic Disorders
Cardiac Disease in Hematologic Disorders Allen P. Burke, M.D. Adina Paulk, M.D. Sickle Cell Disease Sickle cell disease is a chronic hemolytic anemia caused by abnormal hemoglobin that polymerizes and…
Cardiac Disease in Endocrine Disorders
Cardiac Disease in Endocrine Disorders Allen P. Burke, M.D. Adina Paulk, M.D. Introduction The effect of metabolism and endocrine disorders on the heart is multifaceted, and there are no specific…
Cor Pulmonale
Cor Pulmonale Allen P. Burke, M.D. Adina Paulk, M.D. Definition Cor pulmonale, or pulmonary heart disease, is right ventricular enlargement with or without right heart failure resulting from pulmonary hypertension…
Left Ventricular Hypertrophy and Failure
Left Ventricular Hypertrophy and Failure Allen P. Burke, M.D. Joseph J. Maleszewski, M.D. Left Ventricular Hypertrophy Physiology and Causes Cardiac hypertrophy is an adaptive response to an increased load (pressure…
Pathology of Cardiac Devices and Interventions
Pathology of Cardiac Devices and Interventions Joseph J. Maleszewski, M.D. Allen P. Burke, M.D. Introduction Open and percutaneous interventions performed on the heart and thoracic aorta are relatively commonplace. They…
