Cardiac Allograft Vasculopathy
Cardiac Allograft Vasculopathy Joseph J. Maleszewski, M.D. Allen P. Burke, M.D. Overview Cardiac allograft vasculopathy (CAV, or, loosely, chronic rejection) is a primarily intimal disease that is unique to allograft…
Evaluation of Excised Cardiac Valves
Evaluation of Excised Cardiac Valves Allen P. Burke, M.D. General Considerations A gross photograph generally provides significantly more information than do histologic sections or long gross descriptions. However, histologic evaluation…
Antibody-Mediated Cardiac Allograft Rejection
Antibody-Mediated Cardiac Allograft Rejection Allen P. Burke, M.D. Introduction Antibody-mediated rejection is an immunologic response to the cardiac allograft distinct from cellular rejection by its biology and histologic findings. It…
Acute Cellular Rejection
Acute Cellular Rejection Allen P. Burke, M.D. Fabio R. Tavora, M.D., Ph.D. Introduction Endomyocardial biopsy surveillance, with frequent biopsies in the early months and standardized treatments for particular clinical situations,…
Pericarditis
Pericarditis Fabio R. Tavora, M.D., Ph.D. Allen P. Burke, M.D. Incidence and Clinical Findings Pericardial inflammation can be the result of infections, autoimmune disease, renal failure, radiation, malignancy, or trauma…
Infections of the Myocardium
Infections of the Myocardium Fabio R. Tavora, M.D., Ph.D. Allen P. Burke, M.D. Viral and Postviral Myocarditis Coxsackievirus type B is a type of enterovirus that causes a flu-like systemic…
Giant Cell Myocarditis
Giant Cell Myocarditis Allen P. Burke, M.D. Pathogenesis Historically termed “Fiedler myocarditis,”1 giant cell myocarditis is a rare disorder with unclear cause. An autoimmune cause is likely, because patients often…
Hypersensitivity, Eosinophilic, and Toxic Myocarditis
Hypersensitivity, Eosinophilic, and Toxic Myocarditis Allen P. Burke, M.D. Definitions “Hypersensitivity myocarditis” is an etiologic definition that denotes a reaction to an ingested substance, usually a drug, that usually, but…
Lymphocytic Myocarditis
Lymphocytic Myocarditis Fabio R. Tavora, M.D., Ph.D. Allen P. Burke, M.D. Pathogenesis “Lymphocytic myocarditis” describes the histologic pattern of the most common form of myocarditis, which is associated with viruses…
Restrictive Cardiomyopathy, Endocardial Fibrosis, and Eosinophilic Endomyocarditis
Restrictive Cardiomyopathy, Endocardial Fibrosis, and Eosinophilic Endomyocarditis Fabio R. Tavora, M.D., Ph.D. Allen P. Burke, M.D. Restrictive Heart Disease Restrictive heart disease refers to hemodynamic cardiac alterations that result from…
