Congenital Cysts and Malformations
Congenital Cysts and Malformations Haresh Mani, M.D. Jennifer M. Boland, M.D. Overview Most surgical lung specimens from children are resections of cystic lesions and malformations, which are usually treated by…
Pulmonary Hypoplasia
Pulmonary Hypoplasia Jennifer M. Boland, M.D. Marie-Christine Aubry, M.D. Definition Pulmonary hypoplasia (PH) is an incomplete development of the lung, primarily due to a decreased amount of alveolated parenchyma, although…
Pulmonary Computed Tomography
Pulmonary Computed Tomography Seth Kligerman, M.D. Allen P. Burke, M.D. Chest CT: General Aspects Technical Considerations Advances in CT technology over the past few decades have let to improvements in…
Approach to the Diagnosis of Nonneoplastic Parenchymal Lung Nodules
Approach to the Diagnosis of Nonneoplastic Parenchymal Lung Nodules Allen P. Burke, M.D. Marie-Christine Aubry, M.D. Haresh Mani, M.D. Poorly Formed Granulomas Granulomas in the lung parenchyma are generally classified…
Pathologic Changes in Pulmonary Vessels
Pathologic Changes in Pulmonary Vessels Allen P. Burke, M.D. Joseph J. Maleszewski, M.D. Arterial Changes, Elastic Pulmonary Arteries Thromboembolism Thrombus within the central pulmonary arteries is typically related to embolic…
Patterns of Airway Injury
Patterns of Airway Injury Allen P. Burke, M.D. Haresh Mani, M.D. Bronchiolocentric Inflammation On low magnification, bronchiolocentric inflammation is identified by inflammation around small airways with or without reactive lymphoid…
Alveolar Pneumocytes, Reactive and Metaplastic Changes
Alveolar Pneumocytes, Reactive and Metaplastic Changes Allen P. Burke, M.D. Acute Reactive Changes Alveolar lining cells are denuded and regenerative in acute alveolar injury. Histologic features of regeneration include nuclear…
Organizing Pneumonia
Organizing Pneumonia Allen P. Burke, M.D. Teklu Legesse, M.D. Terminology Organizing pneumonia (OP) is a histologic “pattern” that denotes a subacute phase of lung injury characterized by loose fibrosis that…
Pathologic Processes Involving the Alveolar Spaces
Pathologic Processes Involving the Alveolar Spaces Allen P. Burke, M.D. Haresh Mani, M.D. General Alveolar pathology involves filling of alveolar spaces with acellular material (fluid, blood, protein, or matrix) or…
Diffuse Alveolar Damage
Diffuse Alveolar Damage Marie-Christine Aubry, M.D. Allen P. Burke, M.D. Terminology Diffuse alveolar damage (DAD) is an acute lung injury involving predominantly the interstitium and characterized by two overlapping histologic…
