Introduction Noninvasive testing after presentation with acute myocardial infarction (MI) plays an essential role in patient management. Noninvasive testing complements clinical assessment of risk stratification and can be used to…
Introduction Percutaneous coronary intervention (PCI) is the dominant strategy used for coronary revascularization in acute myocardial infarction (MI). In the United States, approximately 600,000 patients are discharged from the hospital…
Introduction There has been a major decline in the incidence of myocardial infarction (MI) in the developed world, with the proportion of ST-elevation MI (STEMI) decreasing and the proportion of…
Introduction The combination of aspirin with P2Y 12 inhibitors, which is also known as dual antiplatelet therapy, is the standard of care for oral antiplatelet treatment in patients presenting with…
Introduction Clinical outcomes after acute coronary syndrome (ACS) have significantly improved over time. A significant proportion of the reduction in mortality has been the result of development and adoption of…
Introduction The term “reperfusion injury” refers to cellular damage that occurs during the reperfusion phase after an episode of ischemia. If reperfusion occurs after a short period of ischemia, all…
Introduction Despite improvements in secondary preventive care and risk factor modification, there is a persistently elevated risk of recurrent cardiovascular (CV) events after experiencing a myocardial infarction (MI), with more…
Acknowledgments This work was supported in part by NIH grants P01 HL-78825 and UM1 HL-113530 (CCTRN). Introduction Cell-based therapy is an exciting new treatment modality that has the potential to…
Introduction A non–ST-elevation acute coronary syndrome (NSTE-ACS) is caused by a severe flow-limiting stenosis or acute thrombotic obstruction of a coronary artery (see Chapter 13 ). In the absolute majority…
Introduction Atherosclerotic plaque rupture followed by arterial thrombosis is the major determinant that leads to an acute coronary syndrome (ACS). Platelet adhesion, activation, and aggregation have a pivotal role in…
