The Future of Mechanical Circulatory Support
I. The trail blazed and the pathway ahead As the field of Mechanical Circulatory Support (MCS) reaches into its sixth decade beyond first laboratory experimentation, it behooves us to reflect…
Facilitating Myocardial Recovery
Heart failure (HF) is characterized by a pathologic process known as remodeling that involves progressive enlargement (See Chapter 9 ) of the ventricle, reduction in contractility, and an increase in…
Clinical Trial Results in Mechanical Circulatory Support
Disclosure Dr. Russell is a consultant for Medtronic and serves on the Data and Safety Monitoring Board for the HeartMate 3 trial sponsored by Abbott. Dr. Teuteberg has industry relationships…
The Critical Role of MCS Registries
Origins of Intermacs/Pedimacs In The Artificial Heart: Prototypes, Policies, and Patients: Institute of Medicine Report from 1991, the committee opined that “maintaining a registry of mechanical circulatory support (MCS) recipients…
Regulatory and Reimbursement Landscape for Mechanical Circulatory Support
Introduction A regulatory/reimbursement product plan should be created simultaneously, early in the product development cycle, with the concept of developing ongoing evidence to support appropriate device use. If each is…
Mechanical Circulatory Support in Pediatrics
Introduction Mechanical circulatory support (MCS) for pediatric patients has advanced enormously, since its first reported use in the 1950s by Gibbon, Kirklin, and Lillehei in the form of a cardiopulmonary…
Adverse Events and Mitigation Strategies
Key wordsventricular assist devices, adverse events, stroke, risk factors, vad outcomes, device malfunction Introduction The evolution of ventricular assist devices (VAD) since the year 2000 has allowed patients with…
Left Ventricular Assist Device in Special Population of Patients
Case presentation A 73-year-old retired psychiatrist presents with advanced congestive heart failure (HF) (New York Heart Association [NYHA] class IV). He was healthy until about 3 years ago. On evaluation,…
Right Heart Failure in Patients With Mechanical Circulatory Support
Introduction For end-stage heart failure (HF), heart transplantation or implantation of a left ventricular assist device (LVAD) is lifesaving and provides a significant improvement in quality of life. Despite the…
Psychosocial and Quality of Life Issues in Mechanical Circulatory Support
The use of mechanical circulatory support (MCS) as a long-term therapy for end-stage heart failure is associated with many psychosocial considerations for both patients and their families. These considerations span…
