Ex Vivo Lung Bioengineering
Fig. 8.1 Schematic of ex vivo organ engineering. Autologous cells are obtained by a biopsy from the eventual transplant recipient and expanded in ex vivo culture. A scaffold, either synthetic…
The Role of Stem Cells in Vascular Remodeling in CTEPH
© Springer International Publishing Switzerland 2015Amy Firth and Jason X.-J. Yuan (eds.)Lung Stem Cells in the Epithelium and VasculatureStem Cell Biology and Regenerative Medicine10.1007/978-3-319-16232-4_15 15. The Role of Stem Cells in Vascular Remodeling in CTEPH…
Challenges of Cell Therapy for Lung Diseases and Critical Illnesses
Fig. 6.1 Mechanisms of action of MSCs. MSCs promote benefitial effects through cell-to-cell interactions and through secretion of soluble mediators, microvesicles and whole organelles, that can directly affect many cells,…
Mesothelial Progenitors in Development, Lung Homeostasis, and Tissue Repair
Marker Expression Function Wilm’s tumor1 (WT1) is a zinc finger transcription factor WT1 is expressed in visceral and parietal mesothelial cells, kidney podocytes, and glomerular capillaries WT1 controls organ formation…
The Hope for iPSC in Lung Stem Cell Therapy and Disease Modeling
Advantages Disadvantages References Maloney-based retrovirus Self-silencing in pluripotent cells, efficient Genomic integration, transduces only dividing cells Takahashi and Yamanaka (2006) Polycistronic retrovirus Only single integration event needed Genomic integration,…
Bronchioalveolar Stem Cells in Cancer
© Springer International Publishing Switzerland 2015Amy Firth and Jason X.-J. Yuan (eds.)Lung Stem Cells in the Epithelium and VasculatureStem Cell Biology and Regenerative Medicine10.1007/978-3-319-16232-4_4 4. Bronchioalveolar Stem Cells in Cancer Michael Hiatt1, Orquidea Garcia1, Amber Lundin1 and Barbara Driscoll1 …
Does a Lung Stem Cell Exist?
Fig. 1.1 Schematic representation of epithelial cell types found in airways of the adult mouse lung. The adult airway exhibits compartmentalization of constituent cells along the proximal—distal axis. The proximal…
Stem Cell Niches in the Lung
Fig. 3.1 Illustration of potential stem/progenitor cell niches in the lung of the adult mouse. The lung can be divided into three major levels of conducting airways (the trachea, bronchi,…
