Fig. 16.1 This schematic places pulmonary vascular cell apoptosis, in particular endothelial cell apoptosis, in the center of the lung vascular remodeling process which results in exuberant wound healing. Autophagy…
Fig. 18.1 Mesenchymal stromal cell (MSC) differentiation was confirmed via multi-lineage differentiation. (a, b) WT and BMPR2 mutant iPSC were differentiated to MSC. Subsequent MSC were analyzed for their potential…
Fig. 11.1 Proangiogenic hematopoietic cells may interact with resident endothelial progenitor cells to promote neoangiogenesis. Circulating hematopoietic (bone marrow-derived) cells are proposed to provide paracrine signals that stimulate resident endothelial…
Fig. 9.1 Classification of endothelial cell colonies. Endothelial cell colonies are isolated from mononuclear cell fractions of cord blood, peripheral blood circulation, or derived from endothelial cell cultures after single…
Fig. 2.1 A model showing type II cell progenitor functions following alveoli injury. (a) Schematic representation of alveoli. (b) Section of mouse lung alveoli region stained by type II cell…
Fig. 13.1 (a) Immunofluorescence for CXCL12, CXCR4, CXCR7, and c-kit in mice lung exposed to chronic hypoxia (10 % oxygen for 3 weeks) or normoxia. Scale bars = 50 μm; (b) Pulmonary…
Fig. 17.1 Significant differences between early and late outgrowth EPCs. Most importantly, late outgrowth EPCs are highly proliferative and are able to independently form a vascular network. Early outgrowth EPCs…
Fig. 14.1 Pathobiology of pulmonary vascular remodeling in pulmonary hypertension. The pulmonary artery is normally characterized by a single endothelial monolayer, a smooth muscle medial layer, and an adventitial layer….
Fig. 12.1 The pulmonary arterial vascular tree. The pulmonary arterial circulation is characterized by a gradual loss of complexity and muscularization from proximal to distal branches of the vascular tree…
Fig. 5.1 Human cells are found in the lungs of bleomycin-treated mice after transplantation with hES cells differentiated into lung lineage-specific cells. 3,3′-Diaminobenzidine (DAB) immunocytochemistry using anti-human nuclear factor antibody…
