Significant studies Combination of cardiovascular telemetry data collection with calorimetry studies allowed to determine metabolic rates in rodents [46] Combination of telemetric blood pressure measurement with flowprobes to simultaneously monitor…
Tracer Biologic target Blood flow 13N-ammonia Perfusion 82Rb Perfusion 15O-water Perfusion Metabolism 18F-FDG Glucose transport, glucose metabolism 11C-palmitate Fatty acid metabolism 11C-acetate Oxidative metabolism (TCA cycle turnover) Innervation 11C-hydroxyephedrine Presynaptic…
Fig. 3.1 Schematic illustration of the principles governing the movement of ions through membranes. The membrane separating the two sides of the container is permeable to ion X+ but not…
Fig. 23.1 Selected molecular imaging targets in atherosclerosis. (a) PET-CT imaging of adhesion molecule expression in apoE/mice with the 18F -VCAM–1 ligand. (b) Gd-loaded microvesicles targeted to oxLDL macrophage receptor,…
Fig. 18.1 Representative examples of [Ca2+]i and AP alternans. (a) Representative example of concordant [Ca2+]i and AP alternans in a left ventricular canine myocyte stimulated every 0.8 s. The arrows…
Adhesion molecule Alternative designation Localisation Ligand Function Basal expression Selectin family P-selectin CD62P Endothelial cell L-selectin Rolling Yes PADGEM Platelet PSGL-1 GMP-140 120 kD PSL E-selectin CD62E Endothelial cell L-selectin…
Fig. 25.1 Familial Cardiomyopathies and genetic substrate (Image modified from original image courtesy of EKKAN) Fig. 25.2 Cardiomyopathies and overlapping in genetic substrates (Image reproduced courtesy of EKKAN) 25.1.1 Incomplete…
Fig. 17.1 Electron micrograph of an isolated adult cardiocyte A second thesis was supported since a long time by the group of Piero Anversa [12] (Fig. 17.2). According to Anversa…
Fig. 10.1 Excitation-contraction coupling in cardiac muscle. The initial event in the cardiac muscle contraction is membrane depolarization, which occurs with ion entry through connexon channels from a neighboring cardiomyocyte,…
Fig. 16.1 The inflammatory phase of cardiac repair. Release of damage-associated molecular patterns (DAMPs) by dying cardiomyocytes and matrix fragments activates innate immune pathways leading to recruitment of leukocytes in…
