Definition of IPF
Fig. 1.1 Diagnostic algorithm for idiopathic pulmonary fibrosis (IPF). Patients with suspected IPF should be carefully evaluated for identifiable causes of interstitial lung disease (ILD). In the absence of an…
Fig. 1.1 Diagnostic algorithm for idiopathic pulmonary fibrosis (IPF). Patients with suspected IPF should be carefully evaluated for identifiable causes of interstitial lung disease (ILD). In the absence of an…
Fig. 9.1 Pathogenesis of IPF and the mechanism of action of antifibrotic agents 9.3 Pirfenidone 9.3.1 Mechanism of Action Animal studies have shown that pirfenidone suppresses accumulation of inflammatory cells…
1. IPF is defined as a specific form of chronic, progressive fibrosing interstitial pneumonia of unknown cause, occurring primarily in older adults, limited to the lungs, and associated with the…
Fig. 4.1 Schematic drawing of the proposed molecular pathogenesis of IPF. AEC, alveolar epithelial cell; EMT, epithelial-mesenchymal transition; ECM, extracellular matrix 4.2 Epithelial Injury and Genetic Background Studies of the…
Fig. 2.1 Alveolar epithelial cells are thought to be the initial lesion of lung injury caused by environmental factors, such as smoking, inhalational agents, drugs, oxygen radicals, toxins, and viruses,…