Immunotherapy and Lung Cancer
Summary of Key Points • Immunotherapy has entered a new era in lung cancer and is rapidly changing the standard of care. • Vaccines as monotherapies have shown marginal efficacy…
Neurotoxicity Related to Radiotherapy and Chemotherapy for Nonsmall Cell and Small Cell Lung Cancer
Summary of Key Points • Radiation-induced brachial plexopathy (RIBP) occurs with treatment of apical tumors and is frequently complicated by tumor-related brachial plexopathy (TRBP). Stereotactic ablative radiotherapy (SABR) of apical…
How to Promote and Organize Clinical Research in Lung Cancer
Abstract Clinical trials for lung cancer are needed to investigate new treatment or preventative options and to improve outcomes for patients with lung cancer. Times are changing; clinical researchers now…
Malignant Mesothelioma
Summary of Key Points • Development of malignant mesothelioma is usually associated with asbestos exposure. • The most common genetic alterations in mesothelioma are deletion of CDKN2A/ARF , inactivation of…
Treatment of Extensive-Stage Small Cell Lung Cancer
Abstract This chapter discusses first-line and second-line therapy for patients with extensive-stage small cell lung cancer (ED SCLC). As first-line therapy, a platinum agent plus etoposide or irinotecan remains the…
Clinical Trial Methodology in Lung Cancer: Study Design and End-Point Considerations
Summary of Key Points • Lung cancer is increasingly understood at the molecular level; N-of-1 trials are becoming more relevant with the use of biomarker assessment and targeted therapies. •…
The Role of Palliative Care in Lung Cancer
Summary of Key Points • The best palliative outcomes are obtained when palliative care is involved early in advanced lung cancer. • Integration of palliative care early in the advanced…
The Role of Advocacy Groups in Lung Cancer
Summary of Key Points † Deceased. • To describe the functions of advocacy. • To describe how lung cancer advocacy groups accomplish their goals. • To describe how they can…
The Role of Health Services Research in Improving the Outcomes for Patients With Lung Cancer
Summary of Key Points • Health services research aims to improve the outcomes to treatment for lung cancer by optimizing the accessibility, quality, and efficiency of treatment programs. • Achieving…
Stage I Nonsmall Cell Lung Cancer and Oligometastatic Disease
Summary of Key Points • Stereotactic ablative radiotherapy (SABR) is recommended in treatment guidelines as the nonoperative therapy of choice for early-stage nonsmall cell lung cancer (NSCLC). • SABR can…
