Abstract Preliminary candidate gene and genome-wide association studies (GWAS) suggest that susceptibility to adverse perioperative events, including cardiac (myocardial infarction, ventricular dysfunction, atrial fibrillation), neurologic, and renal (among others) is…
Abstract This chapter will apply the principles and concepts introduced in the “Pharmacogenetics and Pharmacogenomics” chapter in volume 2, namely, discussion of four classes of genetic variants that underlie drug…
Abstract It has long been known that there is a heritable component to coronary artery disease (CAD). However, identifying the actual genetic loci influencing CAD risk was not possible prior…
Abstract Ischemic stroke, which is caused by blockage of vessels supplying blood to the brain, represents approximately 87% of all strokes in the United States. While a significant heritable component…
Abstract Abnormalities of cardiac rhythm are important causes of cardiovascular disability, stroke, and sudden cardiac death. Two general approaches have been used to identify genes playing a role in arrhythmia…
Abstract Advances in mouse and human genome research have dramatically altered the landscape and pace of advances in the diagnosis and treatment and many diseases. Peripheral arterial disease (PAD) is…
Abstract This chapter focuses on the impact of genetics and genomics on heart failure. Part one outlines how genetics provides insight to the underpinnings of heart failure. Part two highlights…
Abstract A substantial burden of cardiovascular disease results from thrombosis that manifests clinically as acute coronary syndrome, stroke, and venous thromboembolism. Although antithrombotic drugs that inhibit platelets and coagulation factors…
Abstract Congenital heart disease (CHD) is the most common birth defect. Despite considerable advances in care, CHD remains a major contributor to newborn mortality and is associated with substantial morbidities…
Abstract Hypertrophic cardiomyopathy (HCM) is a relatively common, primary disorder of the myocardium characterized by unexplained left ventricular hypertrophy affecting perhaps as many as 1 in 500 people. HCM is…
