Figure 27–1. Compendium of LQTS-susceptibility genes Rare subtypes stem from perturbations in key cardiac channel interacting proteins [Kv7.1, Kv11.1 or Nav1.5 beta subunits (LQT5, LQT6, LQT10, LQT11, LQT12) or structural…
Figure 31–1. RyR2 mutational clusters. Clusters with frequent mutations are depicted with their location along RyR2 amino acid (AA) sequence. Percentage of known (published) mutation foe each cluster is also…
Figure 13–1. High amplitude spike discharge activity (HASDA) induced ventricular tachycardia (VT) (Panel a), premature ventricular contraction (PVC, arrow) (Panel b) and QRST morphology change (arrows, Panel c) in dogs…
Figure 28–1. Four ECG traces of a resuscitated Brugada syndrome patient showing most severe ST-T abnormalities in leads positioned over the second and third intercostal space (right two panels) where…
Figure 36–1. Typical example of idiopathic VF. This 54 year old female was referred for neurological consultation because of “recurrent seizures”. Her baseline electrocardiogram shows sinus rhythm with normal PR,…
Figure 14–1. IKr, IKs, and Ito their respective genes and their role in the repolarization of the ventricular action potential Pathologies due to mutation in ion channels were described clinically…
Figure 9–1. Conceptual scheme of cardiac electro-mechanical regulation. Electrical control of cardiac contraction is via Excitation-Contraction Coupling (ECC), while the mechanical environment affects cardiac electrical behaviour via Mechano-Electric Feedback (MEF)…
Figure 2–1. Schematic cardiac electrical activity, from molecule to patient channel: single channel current versus time recorded using the patch-clamp technique, upward inflection of the signal indicates outward current through…
Figure 30–1. Different features of J wave elevation as notching (a) or slurring (b) in inferior or lateral leads in patients with VF Prevalence The prevalence of ER in general…
Lipids Cholesterol Ceramide Sphingomyelin Diacylglycerol (DAG) Cis-unsaturated phospholipids Phosphatidylserine Phosphatidylethanolamine Phosphatidylinositol Phosphatidylinositol bi-phosphate (PIP2) Protein Caveolins (-1, -2, and -3) G-proteins G-alpha, -G-beta Adrenergic receptor (AR) Beta-1, beta-2, beta-3? Cytokine…
