JMHW HRS 2014 Definite diagnosis Histologic evidence of cardiac non-caseating granuloma Histologic evidence of cardiac non- caseating granuloma, with no alternative cause identified (i.e., infection) Probable/clinical diagnosis Histological diagnosis…
Major complications Total <1.0 % Death None Tamponade with pericardiocentesis 0.08–0.80 % Hemothorax or pneumothorax None Permanent complete AV block with permanent pacemaker needed <0.04 % Urgent cardiac surgery…
Genetics: chromosomal abnormalities, angiotensin-converting enzyme genes T cell abnormalities T cell receptor abnormalities Vitamin D receptor gene abnormalities Viruses: HHV Mycobacterial diseases and acid-fast cell wall-deficient organisms Beryllium exposure Humidity/water…
Fig. 1.1 A myocardial biopsy obtained via right heart catheterization showing giant cells consistent with sarcoidosis As sarcoidosis is now more widely recognized and with increased rigor in its diagnosis,…
Histologic diagnosis Endomyocardial biopsy demonstrating noncaseating epithelioid granulomas Clinical diagnosis Suspect cardiac sarcoidosis with (a) + one other (a) Complete right bundle branch block, AV block, ventricular tachycardia, ventricular premature…
