Three key proteases – angiotensin-I-converting enzyme (ACE), ACE2 and renin – within and beyond the renin-angiotensin system

Jul 13, 2017 by in CARDIOLOGY Comments Off on Three key proteases – angiotensin-I-converting enzyme (ACE), ACE2 and renin – within and beyond the renin-angiotensin system

Summary The discovery of angiotensin-I-converting enzyme 2 (ACE2) and a (pro)renin receptor has renewed interest in the physiology of the renin-angiotensin system (RAS). Through the ACE2/angiotensin-(1–7)/Mas counter-regulatory axis, ACE2 balances…

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Fetal cardiac interventions: Myths and facts

Jul 13, 2017 by in CARDIOLOGY Comments Off on Fetal cardiac interventions: Myths and facts

Summary An early, primary, in utero cardiac abnormality may prevent normal heart development and cause irreversible secondary structural changes. The idea of foetal cardiac intervention stems from this understanding and…

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Optimization of heart FailUre medical Treatment after hospital discharge according to left ventricUlaR Ejection fraction: The FUTURE survey

Jul 13, 2017 by in CARDIOLOGY Comments Off on Optimization of heart FailUre medical Treatment after hospital discharge according to left ventricUlaR Ejection fraction: The FUTURE survey

Summary Background No clinical practice guidelines are available for the treatment of heart failure (HF) in patients with preserved left ventricular ejection fraction (LVEF). Aims To determine how cardiologists manage…

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Comparison of bleeding complications and 3-year survival with low-molecular-weight heparin versus unfractionated heparin for acute myocardial infarction: The FAST-MI registry

Jul 13, 2017 by in CARDIOLOGY Comments Off on Comparison of bleeding complications and 3-year survival with low-molecular-weight heparin versus unfractionated heparin for acute myocardial infarction: The FAST-MI registry

Summary Background Recent clinical studies suggest that low-molecular-weight heparin (LMWH) could be an effective and safe alternative to unfractionated heparin (UFH) for patients with acute myocardial infarction (AMI). Aims To…

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Early triage of emergency department patients with acute coronary syndrome: Contribution of 64-slice computed tomography angiography

Jul 13, 2017 by in CARDIOLOGY Comments Off on Early triage of emergency department patients with acute coronary syndrome: Contribution of 64-slice computed tomography angiography

Summary Background Multislice computed tomography coronary angiography (MSCT-CA) is feasible in the emergency department (ED) for ruling out obstructive coronary artery disease (CAD). Aim To investigate a diagnostic strategy using…

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