Design and rationale of RECOVER-AUTONOMIC: A randomized platform trial evaluating interventions for Long COVID postural orthostatic tachycardia syndrome

Jun 27, 2026 by in CARDIOLOGY Comments Off on Design and rationale of RECOVER-AUTONOMIC: A randomized platform trial evaluating interventions for Long COVID postural orthostatic tachycardia syndrome
Highlights • NIH-sponsored platform RCT in Long COVID postural orthostatic tachycardia syndrome. • Tests intravenous immunoglobulin and ivabradine vs placebo. • Factorial design includes coordinated care vs usual care. •…
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Association between atherosclerosis and atrial fibrillation progression in patients with paroxysmal atrial fibrillation: Data from the RACE V study

Jun 27, 2026 by in CARDIOLOGY Comments Off on Association between atherosclerosis and atrial fibrillation progression in patients with paroxysmal atrial fibrillation: Data from the RACE V study
Highlights • Atherosclerosis was present in two-thirds of patients with paroxysmal AF, mostly subclinical. • Patients with atherosclerosis had an increased risk of AF progression. • Atherosclerosis remained a determinant…
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Probabilities of treatment effects in complete or culprit-only revascularization for NSTEMI: A Bayesian re-analysis of the SLIM trial

Jun 27, 2026 by in CARDIOLOGY Comments Off on Probabilities of treatment effects in complete or culprit-only revascularization for NSTEMI: A Bayesian re-analysis of the SLIM trial
Highlights • Bayesian re-analysis quantifies treatment effects beyond P -values. • Complete revascularization shows 91% probability of clinically relevant benefit. • Benefit driven by fewer repeat revascularizations and non-fatal myocardial…
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Left Atrial Appendage Occlusion Versus NOACs in patients With Atrial Fibrillation: Rationale and Design of the CATALYST Trial

Jun 27, 2026 by in CARDIOLOGY Comments Off on Left Atrial Appendage Occlusion Versus NOACs in patients With Atrial Fibrillation: Rationale and Design of the CATALYST Trial
Highlights • CATALYST compares Amulet LAAO vs. NOACs in AF patients at elevated stroke risk. • Three co-primary endpoints assess stroke, systemic embolism, CV death, and bleeding. • Post-LAAO care…
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Associations between practice-level compliance with cardiac performance measures and clinical outcomes in US cardiovascular ambulatory care

Jun 27, 2026 by in CARDIOLOGY Comments Off on Associations between practice-level compliance with cardiac performance measures and clinical outcomes in US cardiovascular ambulatory care
Clinical question: Is practice-level compliance with cardiac performance measures associated with clinical outcomes in ambulatory care? Main findings: Heart failure composite and individual performance measure compliance related to beta-blocker and…
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Safety of a remote disease management program to improve sodium-glucose cotransporter-2 inhibitors and glucagon-like peptide-1 receptor agonists prescribing in type 2 diabetes with elevated cardiovascular or kidney risk

Jun 27, 2026 by in CARDIOLOGY Comments Off on Safety of a remote disease management program to improve sodium-glucose cotransporter-2 inhibitors and glucagon-like peptide-1 receptor agonists prescribing in type 2 diabetes with elevated cardiovascular or kidney risk
Highlights • Remote pharmacist-led care safely initiated SGLT2i and GLP1 RA in high-risk T2D. • AE rates matched clinical trials: 29% for SGLT2i, 55% for GLP1 RA initiators. • Only…
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STrategies for antithrombotic tRreatment following transcatheter edge-to-edge repair in patients with severe mitral regurgitation: Rationale and design of STAR-TEER trial

Jun 27, 2026 by in CARDIOLOGY Comments Off on STrategies for antithrombotic tRreatment following transcatheter edge-to-edge repair in patients with severe mitral regurgitation: Rationale and design of STAR-TEER trial
Highlights • Antithrombotic therapy following transcatheter edge-to-edge repair is essential to mitigate ischemic complications, whereas no randomized controlled trial has established the optimal anticoagulation strategies. • STAR-TEER trial is an…
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Study design for an emulated trial of a 2 arm, parallel, stratified, adaptive, RCT of CABG versus PCI in people requiring myocardial revascularization at high risk (High-Risk REVASC)

Jun 27, 2026 by in CARDIOLOGY Comments Off on Study design for an emulated trial of a 2 arm, parallel, stratified, adaptive, RCT of CABG versus PCI in people requiring myocardial revascularization at high risk (High-Risk REVASC)
ABSTRACT Aim This study aims to use routinely collected health data and trial emulation methodology to inform the design of a pragmatic randomized controlled trial (RCT) in people requiring multivessel…
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