Fig. 2.1 Distribution of left ventricular ejection fraction measured in women and men enrolled in the EuroHeart Failure survey (From Cleland et al. [4]) The incidence of HF and its…
Fig. 1.1 Distinct pharmacological approach to bock the renin-angiotensin system (RAS) AT1 receptors belong to the superfamily of G-protein–coupled receptors that contain seven trans-membrane regions and are localized in the…
Trial Drug Patients Primary outcomes Main conclusions SOLVD The SOLVD Investigators [55] Enalapril vs placebo 6,797 patients with ejection fractions ≤ 0.35 Death from any cause, hospitalizations for heart failure Enalapril reduced…
ONTARGET ALTITUDE VA NEPHRON-D N 25,620 8,561 1,448 Study groups Ramipril 10 mg, Telmisartan 80 mg, combination of both Aliskiren 300 mg versus placebo on top of ACEI or…
