Methods
Consecutive patients with STEMI undergoing primary PCI in a single tertiary cardiac center were enrolled. High-sensitivity CRP was measured by immunonephelometric method before coronary angiography on admission. Cox regression analysis was performed to calculate hazard ratios (HR) of events with 95% confidence intervals (CI).
Methods
Consecutive patients with STEMI undergoing primary PCI in a single tertiary cardiac center were enrolled. High-sensitivity CRP was measured by immunonephelometric method before coronary angiography on admission. Cox regression analysis was performed to calculate hazard ratios (HR) of events with 95% confidence intervals (CI).
Results
A total of 449 patients, 65.4 (55.9 ± 73.8) yrs old, 322 (71.7%) males, were enrolled. Baseline CRP levels were significantly higher in patients who died ( N = 57) compared to those who remained alive [0.8 mg/dl (25th–75th percentile, 0.3–5.9 mg/dl) vs. 0.4 mg/dl (25th–75th percentile, 0.2–0.9 mg/dl), P < .001], and in patients experiencing the composite of death, non fatal myocardial infarction, target lesion or vessel revascularization, and hospitalization for heart failure (i.e. MACEs) ( N = 140) compared to those without MACEs [0.52 mg/dl (25th–75th percentile, 0.27–2.72 mg/dl) vs. 0.39 mg/dl (25th–75th percentile, 0.2–0.8 mg/dl), P = .0001]. At multiple Cox regression analysis at a median follow-up of 1048 days (25th–75th percentile, 839–1334 days), CRP levels, as continuous variable, and top quartile CRP levels (i.e. CRP ≥ 1 mg/dl) were significant predictors of mortality [HR 1.09, 95% CI (1.05–1.13), < 0.001; and HR 2.85, 95% CI (1.59–5.13), P < .001, respectively], and of MACEs [HR 1.06, 95% CI (1.03–1.09), P < .001), and HR 1.96, 95% CI (1.36–2.83), P < .001, respectively].
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